The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.
The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.
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DOI：
10.1016/j.cmet.2011.01.005
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发表时间：
2011-02-02
期刊：
影响因子：
29
通讯作者：
Thummel CS
中科院分区：
文献类型：
--
作者：
Tennessen JM;Baker KD;Lam G;Evans J;Thummel CS
新陈代谢必须与发育相协调，为生命周期的每个阶段提供适当的能量需求。然而，人们对这种暂时的控制是如何实现的知之甚少。在这里，我们展示了雌激素相关受体（ERR）家族核受体的果蝇同源物在发育过程中指导了一个关键的代谢转变。dERR突变体在幼虫时死亡，ATP水平低，循环糖水平升高。在胚胎中期，活性dERR蛋白的表达触发了基因表达的坐标转换，驱动了通常与增殖细胞相关的代谢程序，支持了幼虫发育过程中发生的急剧生长。本研究表明，dERR在碳水化合物代谢中起着核心作用，表明增殖代谢程序在正常发育生长中起作用，并为理解哺乳动物ERR家族成员与癌症之间的密切联系提供了分子背景。
Metabolism must be coordinated with development to provide the appropriate energetic needs for each stage in the life cycle. Little is know, however, about how this temporal control is achieved. Here we show that the Drosophila ortholog of the Estrogen-Related Receptor (ERR) family of nuclear receptors directs a critical metabolic transition during development. dERR mutants die as larvae with low ATP levels and elevated levels of circulating sugars. The expression of active dERR protein in mid-embryogenesis triggers a coordinate switch in gene expression that drives a metabolic program normally associated with proliferating cells, supporting the dramatic growth that occurs during larval development. This study shows that dERR plays a central role in carbohydrate metabolism, demonstrates that a proliferative metabolic program is used in normal developmental growth, and provides a molecular context to understand the close association between mammalian ERR family members and cancer.
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DOI：
10.1073/pnas.0400916101
发表时间：
2004-04-27
影响因子：
11.1
作者：
Eisenreich, W;Ettenhuber, C;Bacher, A
通讯作者：
Bacher, A
DOI：
10.1046/j.1440-1681.2002.03655.x
发表时间：
2002-04-01
影响因子：
2.9
作者：
Lehman, JJ;Kelly, DP
通讯作者：
Kelly, DP
影响因子：
4.6
作者：
Palanker, Laura;Necakov, Aleksandar S.;Krause, Henry M.
通讯作者：
Krause, Henry M.
影响因子：
23.8
作者：
Arrese EL;Soulages JL
通讯作者：
Soulages JL
影响因子：
2.2
作者：
MADHAVAN, K;URSPRUNG, H;FOX, DJ
通讯作者：
FOX, DJ