Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.
Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.
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DOI：
10.1038/s41467-023-37797-y
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发表时间：
2023-04-24
影响因子：
16.6
通讯作者：
Qu, Wei-Min
中科院分区：
文献类型：
--
作者：
Guo, Han;Jiang, Jian-Bo;Xu, Wei;Zhang, Mu-Tian;Chen, Hui;Shi, Huan-Ying;Wang, Lu;He, Miao;Lazarus, Michael;Li, Shan-Qun;Huang, Zhi-Li;Qu, Wei-Min
丘脑旁核（PSTN）被认为参与动机，进食和狩猎，所有这些都高度依赖于清醒。然而，PSTN在觉醒中的作用和潜在的神经回路仍然不清楚。表达钙视网膜蛋白（CR）的神经元占PSTN神经元的大多数。在这项对雄性小鼠的研究中，纤维光度记录显示，PSTNCR神经元的活性在从非快速眼动（非REM，NREM）睡眠到觉醒或REM睡眠以及探索行为的过渡中增加。化学遗传学和光遗传学实验表明，PSTNCR神经元是启动和/或维持与探索相关的唤醒所必需的。PSTNCR神经元投射的光活化显示，它们通过支配腹侧被盖区来调节探索相关的觉醒。总的来说，我们的研究结果表明，PSTNCR电路是必不可少的诱导和维持清醒状态与探索。调节清醒的神经回路还没有完全解决。在这里，作者揭示了丘脑旁核中表达钙视网膜蛋白的神经元在诱导和维持与通过投射到腹侧被盖区的探索相关的清醒状态中起着关键作用。
The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding and hunting, all of which are highly depending on wakefulness. However, the roles and underlying neural circuits of the PSTN in wakefulness remain unclear. Neurons expressing calretinin (CR) account for the majority of PSTN neurons. In this study in male mice, fiber photometry recordings showed that the activity of PSTNCR neurons increased at the transitions from non-rapid eye movement (non-REM, NREM) sleep to either wakefulness or REM sleep, as well as exploratory behavior. Chemogenetic and optogenetic experiments demonstrated that PSTNCR neurons were necessary for initiating and/or maintaining arousal associated with exploration. Photoactivation of projections of PSTNCR neurons revealed that they regulated exploration-related wakefulness by innervating the ventral tegmental area. Collectively, our findings indicate that PSTNCR circuitry is essential for the induction and maintenance of the awake state associated with exploration. The neural circuits regulating wakefulness have not been fully resolved. Here, the authors reveal that neurons expressing calretinin in the parasubthalamic nucleus play a key role in the induction and maintenance of the awake state associated with exploration via projections to the ventral tegmental area.
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影响因子：
64.5
作者：
Botta P;Fushiki A;Vicente AM;Hammond LA;Mosberger AC;Gerfen CR;Peterka D;Costa RM
通讯作者：
Costa RM
影响因子：
16.6
作者：
Liu C;Lee CY;Asher G;Cao L;Terakoshi Y;Cao P;Kobayakawa R;Kobayakawa K;Sakurai K;Liu Q
通讯作者：
Liu Q
腹侧苍白球 GABA 能神经元通过腹侧被盖通路控制与动机相关的觉醒
影响因子：
11
作者：
Li YD;Luo YJ;Xu W;Ge J;Cherasse Y;Wang YQ;Lazarus M;Qu WM;Huang ZL
通讯作者：
Huang ZL
影响因子：
25
作者：
Eban-Rothschild A;Rothschild G;Giardino WJ;Jones JR;de Lecea L
通讯作者：
de Lecea L
影响因子：
9.2
作者：
Dong, Hui;Chen, Ze-Ka;Huang, Zhi-Li
通讯作者：
Huang, Zhi-Li