An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration.
An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration.
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DOI：
10.1016/j.cell.2020.09.023
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发表时间：
2020-10-29
期刊：
影响因子：
64.5
通讯作者：
Costa RM
中科院分区：
文献类型：
--
作者：
Botta P;Fushiki A;Vicente AM;Hammond LA;Mosberger AC;Gerfen CR;Peterka D;Costa RM
对新环境的探索确保了生存和进化适应性。它是通过探索性的较量和逮捕，根据经验动态变化。因此，调节探索行为的神经回路应该整合经验，并利用经验来选择适当的行为输出。使用空间探索试验，我们发现了一个经验依赖性的增加，瞬间逮捕的位置，动物逮捕以前。自由探索小鼠的钙成像显示，基底外侧杏仁核中的遗传和投射定义的神经元系综在自主行为停滞期间活跃。这个集合是以经验依赖的方式招募的，对这些神经元的闭环光遗传学操纵表明，它们足以在探索过程中驱动经验依赖性逮捕。投射特异性成像和光遗传学实验表明，这些逮捕是由基底外侧杏仁核神经元投射到中央杏仁核，揭示了杏仁核电路，介导在熟悉的地方瞬间逮捕，但不回避或焦虑/恐惧样行为。一个遗传和投影定义的基底外侧杏仁核电路介导的瞬间逮捕在探索过程中出现的经验依赖的方式，当小鼠熟悉一个新的环境。
Exploration of novel environments ensures survival and evolutionary fitness. It is expressed through exploratory bouts and arrests that change dynamically based on experience. Neural circuits mediating exploratory behavior should therefore integrate experience and use it to select the proper behavioral output. Using a spatial exploration assay, we uncovered an experience-dependent increase in momentary arrests in locations where animals arrested previously. Calcium imaging in freely exploring mice revealed a genetically and projection-defined neuronal ensemble in the basolateral amygdala that is active during self-paced behavioral arrests. This ensemble was recruited in an experience-dependent manner, and closed-loop optogenetic manipulation of these neurons revealed that they are sufficient and necessary to drive experience-dependent arrests during exploration. Projection-specific imaging and optogenetic experiments revealed that these arrests are effected by basolateral amygdala neurons projecting to the central amygdala, uncovering an amygdala circuit that mediates momentary arrests in familiar places but not avoidance or anxiety/fear-like behaviors. A genetically and projection-defined basolateral amygdala circuit mediates momentary arrests during exploration that emerge in an experience-dependent manner when mice familiarize themselves with a novel environment.
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