Membrane adhesion and the formation of heterogeneities: biology, biophysics, and biotechnology.

Membrane adhesion and the formation of heterogeneities: biology, biophysics, and biotechnology.
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DOI:
10.1039/c4cp05876c
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发表时间:
2015-06-28
期刊:
Physical chemistry chemical physics : PCCP
影响因子:
--
通讯作者:
Shindell O
Shindell O
中科院分区:
其他
文献类型:
--
作者:
Gordon VD;O'Halloran TJ;Shindell O

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膜粘附对许多重要的生物过程至关重要。膜粘附的部位通常与膜的脂质和蛋白质组成的异质性有关。这些异质性被认为通过促进蛋白质之间的相互作用发挥功能作用。然而,膜粘附和膜异质性之间的因果关系尚不清楚。在这里,我们调查了该领域的现状,并指出了我们认为尚未得到充分研究的领域。
Membrane adhesion is essential to many vital biological processes. Sites of membrane adhesion are often associated with heterogeneities in the lipid and protein composition of the membrane. These heterogeneities are thought to play functional roles by facilitating interactions between proteins. However, the causal links between membrane adhesion and membrane heterogeneities are not known. Here we survey the state of the field and indicate what we think are understudied areas ripe for development.
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