Tumor-mesoporous silica nanoparticle interactions following intraperitoneal delivery for targeting peritoneal metastasis.
Tumor-mesoporous silica nanoparticle interactions following intraperitoneal delivery for targeting peritoneal metastasis.
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肿瘤-介孔二氧化硅纳米颗粒在腹腔内靶向腹腔转移后的相互作用。
DOI：
10.1016/j.jconrel.2020.11.003
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发表时间：
2020-12-10
期刊：
影响因子：
--
通讯作者：
Lu X
中科院分区：
文献类型：
--
作者：
Hargrove D;Liang B;Kashfi-Sadabad R;Joshi GN;Gonzalez-Fajardo L;Glass S;Jay M;Salner A;Lu X
据报道，腹腔注射纳米颗粒可促进转移性腹膜肿瘤中纳米颗粒浓度的提高。虽然这一策略对限制纳米载体传递的有毒物质的全身暴露和增加无血管腹膜肿瘤中的纳米颗粒浓度很有吸引力，但对纳米颗粒在肿瘤组织上积聚的机制知之甚少，目前还没有纳米颗粒基产品被批准用于腹腔内给药。在这里，我们使用MCM-41型介孔二氧化硅纳米颗粒作为我们的模型系统，研究了导致腹膜肿瘤积聚增加的纳米颗粒特异性特征。我们还研究了腹膜肿瘤基质中促进纳米颗粒-肿瘤相互作用的成分。肿瘤细胞外基质是驱动这些相互作用的主要因素，特别是纳米颗粒与胶原蛋白的相互作用。破坏胶原基质后，纳米颗粒的积累减少了50%。同样值得注意的是，靶向配体的掺入并没有增加体内肿瘤的总体积累，但在体外却显著增加了纳米颗粒的积累。其他颗粒化学物质的使用不会严重影响肿瘤的靶向性，但当这些测试颗粒显示出显著的全身暴露时，就会引起额外的关注。介孔二氧化硅纳米颗粒由于其物理稳定性、肿瘤靶向性、与胶原基质的强相互作用以及延长的腹膜停留时间，有利于腹腔给药治疗腹膜转移。最大化纳米颗粒与肿瘤细胞外基质的相互作用对于开发利用纳米载体治疗腹膜癌的新疗法至关重要。
The use of intraperitoneal administration of nanoparticles has been reported to facilitate higher concentrations of nanoparticles in metastatic peritoneal tumors. While this strategy is appealing for limiting systemic exposure of nanocarrier delivered toxic cargoes and increasing nanoparticle concentrations in avascular peritoneal tumors, little is known about the mechanism of nanoparticle accumulation on tumor tissues and currently, no nanoparticle-based product has been approved for intraperitoneal delivery. Here, we investigated the nanoparticle-specific characteristics that led to increased peritoneal tumor accumulation using MCM-41 type mesoporous silica nanoparticles as our model system. We also investigated the components of the peritoneal tumor stroma that facilitated nanoparticle-tumor interaction. The tumor extracellular matrix is the main factor driving these interactions, specifically the interaction of nanoparticles with collagen. Upon disruption of the collagen matrix, nanoparticle accumulation was reduced by 50%. It is also notable that the incorporation of targeting ligands did not increase overall tumor accumulation in vivo while it significantly increased nanoparticle accumulation in vitro. The use of other particle chemistries did not grossly affect the tumor targetability, but additional concerns arose when those tested particles exhibited significant systemic exposure. Mesoporous silica nanoparticles are advantageous for intraperitoneal administration for the treatment of peritoneal metastasis due to their physical stability, tumor targetability, strong interaction with the collagen matrix, and extended peritoneal residence time. Maximizing nanoparticle interaction with the tumor extracellular matrix is critical for developing strategies to deliver emerging therapeutics for peritoneal cancer treatment using nanocarriers.
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DOI：
10.1016/j.nano.2016.04.013
发表时间：
2016-10
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
Fu Q;Hargrove D;Lu X
通讯作者：
Lu X
影响因子：
14
作者：
Liu R;Colby AH;Gilmore D;Schulz M;Zeng J;Padera RF;Shirihai O;Grinstaff MW;Colson YL
通讯作者：
Colson YL
癌症相关成纤维细胞靶向脂质体全面启动肿瘤微环境，与癌细胞靶向化疗药物递送系统联合治疗
影响因子：
10.8
作者：
Chen, Binlong;Dai, Wenbing;Zhang, Qiang
通讯作者：
Zhang, Qiang
DOI：
10.1016/j.biocel.2015.11.005
发表时间：
2016-06-01
影响因子：
4
作者：
Graefe, Christine;Weidner, Andreas;Dutz, Silvio
通讯作者：
Dutz, Silvio
功能化的聚苯乙烯纳米颗粒作为研究生物纳米相互作用的平台。
影响因子：
3.1
作者：
Loos C;Syrovets T;Musyanovych A;Mailänder V;Landfester K;Nienhaus GU;Simmet T
通讯作者：
Simmet T