Functionalized polystyrene nanoparticles as a platform for studying bio-nano interactions.
Functionalized polystyrene nanoparticles as a platform for studying bio-nano interactions.
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功能化的聚苯乙烯纳米颗粒作为研究生物纳米相互作用的平台。
DOI：
10.3762/bjnano.5.250
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发表时间：
2014
影响因子：
3.1
通讯作者：
Simmet T
中科院分区：
文献类型：
--
作者：
Loos C;Syrovets T;Musyanovych A;Mailänder V;Landfester K;Nienhaus GU;Simmet T
各种形状、尺寸和携带不同表面改性的材料的纳米颗粒具有许多技术和生物医学应用。然而，纳米颗粒与生物结构相互作用的机制以及它们的生物影响和危害仍然研究得很差。由于其大的表面积与体积比，纳米颗粒通常表现出与块状材料不同的性质。特别是，纳米颗粒的表面化学对于它们在生物介质中的耐久性和溶解性以及它们的生物相容性和生物分布至关重要。聚苯乙烯在细胞环境中不会降解，并且没有短期细胞毒性。由于聚苯乙烯纳米颗粒可以很容易地合成在一个广泛的尺寸与不同的表面功能化，他们非常适合作为模型颗粒，研究各种生物参数的颗粒表面特性的影响。因此，我们利用聚苯乙烯纳米粒子作为一个方便的平台来研究生物纳米相互作用。本文综述了带正电荷和负电荷的聚苯乙烯纳米颗粒的研究，并将其与临床使用的超顺磁性氧化铁纳米颗粒进行了比较。
Nanoparticles of various shapes, sizes, and materials carrying different surface modifications have numerous technological and biomedical applications. Yet, the mechanisms by which nanoparticles interact with biological structures as well as their biological impact and hazards remain poorly investigated. Due to their large surface to volume ratio, nanoparticles usually exhibit properties that differ from those of bulk materials. Particularly, the surface chemistry of the nanoparticles is crucial for their durability and solubility in biological media as well as for their biocompatibility and biodistribution. Polystyrene does not degrade in the cellular environment and exhibits no short-term cytotoxicity. Because polystyrene nanoparticles can be easily synthesized in a wide range of sizes with distinct surface functionalizations, they are perfectly suited as model particles to study the effects of the particle surface characteristics on various biological parameters. Therefore, we have exploited polystyrene nanoparticles as a convenient platform to study bio–nano interactions. This review summarizes studies on positively and negatively charged polystyrene nanoparticles and compares them with clinically used superparamagnetic iron oxide nanoparticles.
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影响因子：
8
作者：
Ekkapongpisit M;Giovia A;Follo C;Caputo G;Isidoro C
通讯作者：
Isidoro C
影响因子：
10
作者：
Fröhlich E;Meindl C;Roblegg E;Ebner B;Absenger M;Pieber TR
通讯作者：
Pieber TR
影响因子：
3.4
作者：
Brown, HA;Lamb, JC;Neal, BH
通讯作者：
Neal, BH
影响因子：
3.5
作者：
Ishisaka, R;Utsumi, T;Utsumi, K
通讯作者：
Utsumi, K
影响因子：
64.8
作者：
Boal, AK;Ilhan, F;Rotello, VM
通讯作者：
Rotello, VM