A Megabase-Scale Deletion is Associated with Phenotypic Variation of Multiple Traits in Maize.
A Megabase-Scale Deletion is Associated with Phenotypic Variation of Multiple Traits in Maize.
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兆碱基级缺失与玉米多种性状的表型变异相关
DOI：
10.1534/genetics.118.301567
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发表时间：
2019-01
期刊：
影响因子：
3.3
通讯作者：
Qiu F
中科院分区：
文献类型：
--
作者：
Han X;Qin Y;Yu F;Ren X;Zhang Z;Qiu F
基因组缺失在玉米（Zea mays L.）在表型变异和适应性进化中起重要作用。然而，人们对这些基因组缺失的生物学功能知之甚少。在这里，我们报告的生物学功能的兆碱基规模的缺失，我们确定了基于位置的克隆的多性状弱化（muw）突变体，这是作为一个单一的隐性基因座遗传。MUW被定位到2号染色体上的5.16-Mb区域。muw突变体中5.16-Mb的缺失导致48个基因的丢失，并导致一系列表型异常，包括叶片萎蔫、产量表现差、株高降低、气孔密度增加和水分快速流失。虽然muw似乎是由于双链断裂修复，不依赖于基因组内DNA同源性，玉米基因的广泛复制可能减轻了其影响，并促进其生存。
Genomic deletions are pervasive in the maize (Zea mays L.) genome, and play important roles in phenotypic variation and adaptive evolution. However, little is known about the biological functions of these genomic deletions. Here, we report the biological function of a megabase-scale deletion, which we identified by position-based cloning of the multi-trait weakened (muw) mutant, which is inherited as a single recessive locus. MUW was mapped to a 5.16-Mb region on chromosome 2. The 5.16-Mb deletion in the muw mutant led to the loss of 48 genes and was responsible for a set of phenotypic abnormities, including wilting leaves, poor yield performance, reduced plant height, increased stomatal density, and rapid water loss. While muw appears to have resulted from double-stranded break repair that was not dependent on intragenomic DNA homology, extensive duplication of maize genes may have mitigated its effects and facilitated its survival.
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DOI：
10.1073/pnas.132259199
发表时间：
2002-07-09
影响因子：
11.1
作者：
Fu, HH;Dooner, HK
通讯作者：
Dooner, HK
蛋白质 sHSP26 通过与玉米 (Zea mays) 中的特定叶绿体蛋白相互作用，提高热应激下叶绿体的性能
影响因子：
3.3
作者：
Hu, Xiuli;Yang, Yanfang;Wang, Wei
通讯作者：
Wang, Wei
影响因子：
30.8
作者：
Chia, Jer-Ming;Song, Chi;Ware, Doreen
通讯作者：
Ware, Doreen
影响因子：
--
作者：
Jennes I;de Jong D;Mees K;Hogendoorn PC;Szuhai K;Wuyts W
通讯作者：
Wuyts W
影响因子：
14.9
作者：
Gorbunova, V;Levy, AA
通讯作者：
Levy, AA