p27Kip1: a key regulator of skeletal muscle satellite cell proliferation.
p27Kip1: a key regulator of skeletal muscle satellite cell proliferation.
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p27Kip1：骨骼肌卫星细胞增殖的关键调节因子。
DOI：
10.1097/00003086-200210001-00026
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发表时间：
2002
影响因子：
4.2
通讯作者：
Booth,FrankW
中科院分区：
文献类型：
--
作者：
Spangenburg,EspenE;Chakravarthy,ManuV;Booth,FrankW
鉴于肌肉减少症的复杂过程，已经假设减少的卫星细胞增殖潜力可能成为旧肌肉再生的限速因素。因此，可以想象，如果卫星细胞增殖能力可以随着年龄的增长而保持或增强，那么肌肉减少症可能会被延迟或预防。本文综述了细胞周期调节因子p27Kip 1及其在卫星细胞增殖能力调节中的作用。骨骼肌卫星细胞的增殖能力和p27 Kip 1蛋白丰度之间存在一种新的负相关关系。引人注目的是，通过腺病毒载体引入异位p27 Kip 1，尽管存在强烈的促有丝分裂刺激，但在增殖培养的卫星细胞中诱导了显著的生长停滞。因此，p27 Kip 1被认为是一个关键的调控因子，特别是在其调节卫星细胞周期进程的能力。在更大的背景下，这些结果暗示p27 Kip 1作为一个关键的分子管理的骨骼肌再生，肥大，或两者兼而有之的调节。
Given the complex process of sarcopenia, it has been postulated that a diminished satellite cell proliferation potential could become rate-limiting to the regrowth of old muscles. Therefore, it is conceivable that if satellite cell proliferative capacity can be maintained or enhanced with advanced age, sarcopenia potentially could be delayed or prevented. The emerging role (s) of a cell cycle regulator, p27Kip 1, and its role in the regulation of satellite cell proliferative capacity are reviewed. A novel inverse association between the proliferation capacity and p27Kip 1 protein abundance in skeletal muscle satellite cells was observed. Strikingly, with the introduction of ectopic p27Kip 1 via an adenovirus vector, there was a marked growth arrest induced in proliferating cultured satellite cells, despite the presence of a strong mitogenic stimulus. Therefore, p27Kip 1 is proposed to be a key regulatory factor, particularly in its ability to regulate satellite cell cycle progression. In the larger context, such results implicate p27Kip 1 as one of the key molecules governing the regulation of skeletal muscle regrowth, hypertrophy, or both.
小鼠单次全身暴露于裂变中子和 Co60 伽马射线后的死亡率比较。
影响因子：
19.7
作者：
H. Vogel;J. Clark;D. L. Jordan
通讯作者：
D. L. Jordan
DOI：
--
发表时间：
1945
期刊：
The American journal of roentgenology and radium therapy
影响因子：
--
作者：
H. Quastler
通讯作者：
H. Quastler
影响因子：
1.7
作者：
MICHALOWSKI, A
通讯作者：
MICHALOWSKI, A