High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma.
High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma.
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STAT3 的高核表达与弥漫性大 B 细胞淋巴瘤的不良预后相关
DOI：
10.1186/1756-8722-4-31
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发表时间：
2011-08-01
影响因子：
28.5
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Wu ZL;Song YQ;Shi YF;Zhu J
背景本研究旨在探讨STAT 3在弥漫性大B细胞淋巴瘤（DLBCL）中的表达及其预后价值。结果19例胃癌组织中STAT 3和磷酸化STAT 3 tyr 705（P-STAT 3）均呈强阳性表达（25.7%）和24例（32.4%），两者表达水平高度一致（P= 0.001）。STAT 3在非生殖中心B细胞样（non-GCB）DLBCL中的核内高表达率高于GCB亚型，但差异无统计学意义（P> 0.061）。STAT 3的高核表达与总生存率（OS）相关（P= 0.005）。多因素考克斯回归分析显示，STAT 3表达是DLBCL患者的独立预后因素，无论是CHOP方案还是R-CHOP方案。
BackgroundThe purpose of the study was to investigate the expression and prognostic value of STAT3 in diffuse large B-cell lymphoma (DLBCL).MethodsSeventy-four DLBCL patients from 2001 to 2007 were reviewed in the study. The STAT3 expression in their tumor tissues was examined using the immunohistochemistry (IHC) method, and evaluated for its association with clinicopathological parameters.ResultsStrong nuclear staining of STAT3 and phosphorylated-STAT3tyr705(P-STAT3) were observed in 19 cases (25.7%) and 24 cases (32.4%), respectively, and the expression levels were highly consistent between them (P= 0.001). The high nuclear expression of STAT3 was more frequent in the non-germinal center B cell-like (non-GCB) DLBCL than that in the GCB subtype, but not reaching significance (P< 0.061). The high nuclear expression of STAT3 was found to be correlated with poor overall survival (OS) (P= 0.005). Multivariate Cox regression analysis showed that the STAT3 expression was an independent prognostic factor for DLBCL patients regardless of CHOP or R-CHOP regimen used as the first-line therapy.ConclusionSTAT3 is more frequently expressed in non-GCB DLBCL than that in GCB subtype, and its strong nuclear expression is correlated with poor OS in DLBCL.
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影响因子：
8
作者：
Niu, GL;Wright, KL;Yu, H
通讯作者：
Yu, H
DOI：
10.1073/pnas.0404100101
发表时间：
2004-07-20
影响因子：
11.1
作者：
Dechow, TN;Pedranzini, L;Bromberg, JF
通讯作者：
Bromberg, JF
影响因子：
50.3
作者：
Kortylewski M;Xin H;Kujawski M;Lee H;Liu Y;Harris T;Drake C;Pardoll D;Yu H
通讯作者：
Yu H
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
影响因子：
51.1
作者：
Pfreundschuh, Michael;Trumper, Lorenz;Loeffler, Markus
通讯作者：
Loeffler, Markus