Ethanol modulation of gene networks: implications for alcoholism.
Ethanol modulation of gene networks: implications for alcoholism.
复制标题
DOI：
10.1016/j.nbd.2011.04.013
复制
发表时间：
2012-01
影响因子：
6.1
通讯作者：
Miles, Michael F.
中科院分区：
文献类型：
--
作者：
Farris, Sean P.;Miles, Michael F.
酒精中毒是一种复杂的疾病，由环境和遗传因素共同影响多个大脑通路，产生各种行为后遗症，包括成瘾。遗传因素导致超过50%的酒精中毒风险，最近的证据表明，大量效应量小的基因可能是这种疾病的分子基础。基因组学（微阵列或RNA-Seq）和遗传学的最新进展已经鉴定出大量影响乙醇行为或酒精中毒本身的潜在候选基因。为了组织这些复杂的信息，研究人员已经开始关注基因网络的贡献，而不是单个基因，在动物模型或行为内表型包括酒精中毒的各种乙醇诱导的行为。本章回顾了一些用于构建基因网络的方法，从基因组数据和一些最近取得的进展，在应用这种方法的乙醇的神经生物学研究。我们表明，在收集基因组数据的快速技术发展，再加上复杂的实验设计和越来越多的复杂工具的集合正在产生新的见解，了解酗酒的分子基础，这种方法有望为治疗发展的新机会。
Alcoholism is a complex disease caused by a confluence of environmental and genetic factors influencing multiple brain pathways to produce a variety of behavioral sequelae, including addiction. Genetic factors contribute to over 50% of the risk for alcoholism and recent evidence points to a large number of genes with small effect sizes as the likely molecular basis for this disease. Recent progress in genomics (microarrays or RNA-Seq) and genetics has led to the identification of a large number of potential candidate genes influencing ethanol behaviors or alcoholism itself. To organize this complex information, investigators have begun to focus on the contribution of gene networks, rather than individual genes, for various ethanol-induced behaviors in animal models or behavioral endophenotypes comprising alcoholism. This chapter reviews some of the methods used for constructing gene networks from genomic data and some of the recent progress made in applying such approaches to the study of the neurobiology of ethanol. We show that rapid technology development in gathering genomic data, together with sophisticated experimental design and a growing collection of sophisticated tools are producing novel insights for understanding the molecular basis of alcoholism and that such approaches promise new opportunities for therapeutic development.
登录
查看更多内容
影响因子：
2.5
作者：
Daniels, GM;Buck, KJ
通讯作者：
Buck, KJ
影响因子：
14.9
作者：
Jensen LJ;Kuhn M;Stark M;Chaffron S;Creevey C;Muller J;Doerks T;Julien P;Roth A;Simonovic M;Bork P;von Mering C
通讯作者：
von Mering C
影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y
DOI：
10.1002/ajmg.b.30346
发表时间：
2006-12-05
影响因子：
2.8
作者：
Johnson, Catherine;Drgon, Tomas;Uhl, George R.
通讯作者：
Uhl, George R.
影响因子：
4.8
作者：
Hassan, S;Duong, B;Miles, MF
通讯作者：
Miles, MF