Synthesis of long T₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging.

Synthesis of long T₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging.
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DOI:
10.1021/nn305462y
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发表时间:
2013-02-26
期刊:
影响因子:
17.1
通讯作者:
Kauzlarich, Susan M.
Kauzlarich, Susan M.
中科院分区:
材料科学1区
文献类型:
--
作者:
Atkins, Tonya M.;Cassidy, Maja C.;Lee, Menyoung;Ganguly, Shreyashi;Marcus, Charles M.;Kauzlarich, Susan M.

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We describe the synthesis, materials characterization and dynamic nuclear polarization (DNP) of amorphous and crystalline silicon nanoparticles for use as hyperpolarized magnetic resonance imaging (MRI) agents. The particles were synthesized by means of a metathesis reaction between sodium silicide (Na4Si4) and silicon tetrachloride (SiCl4) and were surface functionalized with a variety of passivating ligands. The synthesis scheme results in particles of diameter ~10 nm with long size-adjusted 29Si spin lattice relaxation (T1) times (> 600 s), which are retained after hyperpolarization by low temperature DNP.
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