Multimodality imaging probes: design and challenges.
Multimodality imaging probes: design and challenges.
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DOI：
10.1021/cr9003538
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发表时间：
2010-05-12
期刊：
影响因子：
62.1
通讯作者：
Louie, Angelique Y.
中科院分区：
文献类型：
--
作者：
Louie, Angelique Y.
临床诊断成像中模态选择的难题是具有最高灵敏度的模态具有相对较差的分辨率，而具有高分辨率的模态具有相对较差的灵敏度。近年来，结合使用多种模式的想法越来越受欢迎，研究人员已经意识到，通过串联使用不同成像模式，可以利用它们的互补能力来产生很大的效果。随着第一批成功的商业融合仪器的出现，结合成像技术的想法成为主流。1998年，汤森及其同事与西门子医疗公司合作开发了第一台融合PET/CT仪器，并于2001年投入商业使用。“Biograph”被《时代》杂志评为2000年的“年度发明”之一，其成功使得到2003年，所有主要的临床仪器制造商，GE，Philips，CTI和Siemens都可以使用融合PET/CT仪器。1在随后的几年里，PET/CT的销售增长如此强劲，以至于到2006年，几乎没有独立PET仪器的销售;所有PET销售都是多模态系统的一部分。2-4下一波创新是PET/MRI融合仪器，这给PET/CT带来了改善患者安全性和成像能力的希望。虽然PET/MRI仪器的研究与PET/CT几乎同时开始，但合并两种模式的经济和工程挑战减缓了开发，并且第一个用于人体尺度混合扫描仪的商业PET/MRI原型是在2009年。
The conundrum of modality selection in clinical diagnostic imaging is that modalities with the highest sensitivity have relatively poor resolution, while those with high resolution have relatively poor sensitivity. In recent years, the idea of using multiple modalities in conjunction has gained in popularity and researchers have come to realize that the complementary abilities of different imaging modalities could be harnessed to great effect by using them in tandem. The idea of combining imaging technologies moved to the mainstream with the advent of the first successful commercial fused instruments. The first fused PET/CT instrument, developed in 1998 by Townsend and colleagues in collaboration with Siemens Medical, was available commercially in 2001. The “Biograph” was named as one of the “Inventions of the Year” in 2000 by Time magazine, and its success was such that by 2003 fused PET/CT instruments were available from all of the major clinical instrument manufacturers, GE, Philips, CTI, and Siemens. 1 Over the ensuing years, PET/CT sales increased with such vigor that by the year 2006 there were virtually no sales of standalone PET instruments; all PET sales were as part of multimodality systems. 2-4 The next wave of innovation has been in PET/MRI-fused instruments, which have generated much hope for improved patient safety and imaging capability over PET/CT. Although research on PET/MRI instruments was initiated around the same time as PET/CT, the economic and engineering challenges of merging the two modalities slowed development, and the first commercial PET/MRI prototype for a human scale hybrid scanner was
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