Effect of exercise on the induction of mammary carcinogenesis.
Effect of exercise on the induction of mammary carcinogenesis.
复制标题
运动对诱发乳腺癌的影响。
作者：
H. Thompson;A. Ronan;K. Ritacco;A. R. Tagliaferro;L. Meeker
尽管一些流行病学调查报告的数据表明，减少膳食脂肪消耗和增加体力活动水平与降低乳腺癌风险有关，但一些研究的结果并不支持这些观察结果。这种情况背后的一个悬而未决的问题是，受饮食成分、总热量摄入和能量消耗影响的身体肥胖程度是否是影响乳腺癌风险的关键决定因素。这项工作的目的是确定通过运动增加能量消耗是否可以将食用高脂肪饮食的动物中由 7,12-二甲基苯并[a]蒽 (DMBA) 诱发的乳腺癌的发生率降低到在食用低脂肪饮食的久坐动物中观察到的发生水平。雌性 Sprague-Dawley 大鼠在 21 天龄时获得，并维持 5%（w/w）玉米油饮食（AIN-76A）直至其 64 天龄。 50 天龄时，大鼠接受 5 毫克 DMBA 或溶解有致癌物的溶剂。 DMBA 插管后 14 天，他们被随机分为三组之一：5% 脂肪（w/w）、久坐； 24.6% 脂肪（w/w），久坐；或 24.6% 脂肪（w/w），锻炼过。动物在电机驱动的跑步机上以 20 m/min 的带速和 1 度倾斜度锻炼 15 分钟/天，每周 5 天，持续 18 周。与之前的研究结果相一致，高脂肪饮食与低脂肪饮食会增加诱发乳腺癌的数量及其发生率。然而，与接受高脂肪或低脂肪饮食且久坐的动物相比，适度的跑步机运动并没有像假设的那样延缓肿瘤的发展，而是增加了诱发癌症的发病率和数量，并缩短了癌症潜伏期。尽管这些动物的体重比任何一个久坐组的动物都要重，但身体成分并未因所施加的运动方式而改变。这些数据记录了迄今为止尚未报道的中等水平的有氧运动对乳腺癌诱发的影响。
Although data reported in several epidemiological investigations indicate that reduced consumption of dietary fat and increased levels of physical activity are associated with reduced risk for breast cancer, the results of some studies do not support these observations. Underlying this situation is the unanswered question about whether degree of body fatness, which is affected by dietary composition, total caloric intake, and energy expenditure, is the critical determinant affecting breast cancer risk. The objective of this work was to establish whether increasing energy expenditure by exercise would reduce the occurrence of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene (DMBA) in animals consuming a high fat diet to the level of occurrence observed in sedentary animals consuming a low fat diet. Female Sprague-Dawley rats were obtained at 21 days of age and maintained on a 5% (w/w) corn oil diet (AIN-76A) until they were 64 days of age. At 50 days of age, rats received either 5 mg DMBA or the solvent in which the carcinogen was dissolved. Fourteen days after DMBA intubation they were randomized into one of three groups: 5% fat (w/w), sedentary; 24.6% fat (w/w), sedentary; or 24.6% fat (w/w), exercised. Animals were exercised on a motor-driven treadmill at a belt speed of 20 m/min and a 1-degree incline for 15 min/day, 5 days/week for 18 weeks. Feeding a high fat versus a low fat diet increased the number of breast cancers induced and the rate at which they appeared in agreement with previous investigations. However, rather than retarding the development of tumors as was hypothesized, moderate treadmill exercise increased the incidence and number of cancers induced and shortened cancer latency in comparison to animals that received either the high fat or low fat diet and were sedentary. Body composition was not altered by the exercise regime imposed, although these animals weighed more than either sedentary group. These data document a heretofore unreported effect of a moderate level of aerobic work on breast cancer induction.
影响因子：
11.2
作者：
C. Ip;C. A. Carter;M. Ip
通讯作者：
C. Ip;C. A. Carter;M. Ip
维生素 E、动物体育锻炼和组织损伤。
DOI：
--
发表时间：
1984
期刊：
Medical biology
影响因子：
--
作者：
Packer,L
通讯作者：
Packer,L