Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.
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地中海 - DASH饮食干预神经退行性延迟（MIND）研究：MIND饮食对认知衰退随机对照试验的基本原理、设计和基线特征
DOI：
10.1016/j.cct.2021.106270
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发表时间：
2021-03
影响因子：
2.2
通讯作者：
Barnes LL
中科院分区：
文献类型：
--
作者：
Liu X;Morris MC;Dhana K;Ventrelle J;Johnson K;Bishop L;Hollings CS;Boulin A;Laranjo N;Stubbs BJ;Reilly X;Carey VJ;Wang Y;Furtado JD;Marcovina SM;Tangney C;Aggarwal NT;Arfanakis K;Sacks FM;Barnes LL
阿尔茨海默病性痴呆（AD）是美国第六大死因，2020年估计护理费用达3050亿美元。目前没有治愈方法或疗法来改善疾病进展和症状。越来越多的证据表明，以高抗氧化成分著称的饮食对认知功能有益，这显示了饮食干预的预防潜力。
地中海 - DASH干预延缓神经退行性疾病（MIND）研究是一项为期3年的多中心随机对照试验，旨在测试MIND饮食对604名有阿尔茨海默病风险的个体认知功能的影响。
研究招募了年龄在65岁至84岁之间的男性和女性。符合条件的参与者被随机分配到轻度限制热量的MIND饮食组或轻度限制热量的常规饮食组。在基线和随访时将进行认知评估、病史采集、血压测量、人体测量以及血液和尿液样本采集。大约一半的入组参与者将在研究开始和结束时进行磁共振成像（MRI）扫描。
MIND研究的独特之处包括：1）在有风险的人群中测试一种饮食模式，而非单一营养素或食物；2）为参与者提供作为MIND饮食关键成分的食物（即特级初榨橄榄油、蓝莓和坚果）；3）对大脑结构和体积进行MRI扫描，这可能为饮食的影响提供潜在的机制证据。该研究的结果对于制定预防阿尔茨海默病的饮食指南至关重要。
Alzheimer’s dementia (AD) is the sixth leading cause of death in the U.S., with an estimated $305 billion cost of care in 2020. Currently there are no cures or therapies to ameliorate the disease progression and symptoms. Growing evidence links a diet characterized by high antioxidant components with benefits to cognitive function, which is indicative of the preventative potential of dietary interventions. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study is a 3-year, multicenter, randomized controlled trial to test the effects of the MIND diet on cognitive function in 604 individuals at risk for AD. Men and women ages 65 to 84 years were recruited. Eligible participants were randomized to either the MIND diet with mild caloric restriction or their usual diet with mild caloric restriction. Cognitive assessments, medical history, blood pressure, anthropometric measurements, and blood and urine sample collections will be taken at baseline and follow-up visits. MRI scans will be completed on approximately half of the enrolled participants at the start and end of the study. Unique features of the MIND study include: 1) a dietary pattern, rather than single nutrient or food, tested in an at-risk population; 2) foods featured as key components of the MIND diet (i.e. extra-virgin olive oil, blueberries, and nuts) provided for participants; and 3) MRI scans of brain structure and volume that may provide potential mechanistic evidence on the effects of the diet. Results from the study will be crucial to the development of dietary guidelines for the prevention of AD.
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DOI：
10.1017/s1355617712001282
发表时间：
2013-03
影响因子：
2.6
作者：
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2012-03-01
影响因子：
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