CXCR4 is required for the quiescence of primitive hematopoietic cells.
CXCR4 is required for the quiescence of primitive hematopoietic cells.
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DOI：
10.1084/jem.20072513
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发表时间：
2008-04-14
影响因子：
15.3
通讯作者：
Zou, Yong-Rui
中科院分区：
文献类型：
--
作者：
Nie, Yuchun;Han, Yoon-Chi;Zou, Yong-Rui
造血干细胞（HSCs）的静止对于维持HSCs的终身稳定池以维持高度再生的造血系统至关重要。据认为，专门的小生境中的HSC居住控制HSC静止和自我更新之间的平衡，但鲜为人知的是由小生境提供的外在信号，以及这些小生境信号如何调节这种平衡。我们报告说，CXCL 12产生的骨髓（BM）基质细胞不仅是主要的造血干细胞的趋化因子，但也是一个调节因子，控制原始造血细胞的静止。向培养物中添加CXCL 12抑制原始造血细胞进入细胞周期，并且HSC中其受体CXCR 4的失活导致HSC过度增殖。值得注意的是，过度增殖的Cxcr 4 −/− HSC能够维持稳定的干细胞区室并维持造血。因此，我们提出CXCR 4/CXCL 12信号传导对于将HSC限制在适当的小生境中并控制其增殖是必不可少的。
The quiescence of hematopoietic stem cells (HSCs) is critical for preserving a lifelong steady pool of HSCs to sustain the highly regenerative hematopoietic system. It is thought that specialized niches in which HSCs reside control the balance between HSC quiescence and self-renewal, yet little is known about the extrinsic signals provided by the niche and how these niche signals regulate such a balance. We report that CXCL12 produced by bone marrow (BM) stromal cells is not only the major chemoattractant for HSCs but also a regulatory factor that controls the quiescence of primitive hematopoietic cells. Addition of CXCL12 into the culture inhibits entry of primitive hematopoietic cells into the cell cycle, and inactivation of its receptor CXCR4 in HSCs causes excessive HSC proliferation. Notably, the hyperproliferative Cxcr4 −/− HSCs are able to maintain a stable stem cell compartment and sustain hematopoiesis. Thus, we propose that CXCR4/CXCL12 signaling is essential to confine HSCs in the proper niche and controls their proliferation.
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影响因子：
64.8
作者：
Hock, H;Hamblen, MJ;Orkin, SH
通讯作者：
Orkin, SH
DOI：
10.1073/pnas.95.16.9448
发表时间：
1998-08-04
影响因子：
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20.3
作者：
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通讯作者：
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DOI：
10.1016/j.bbrc.2005.09.008
发表时间：
2005-11-11
影响因子：
3.1
作者：
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