Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment.
Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment.
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自噬调节和光动力疗法：改善癌症治疗预后的见解。
DOI：
10.3389/fonc.2020.610472
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发表时间：
2020
影响因子：
4.7
通讯作者：
Tsubone TM
中科院分区：
文献类型：
--
作者：
Martins WK;Belotto R;Silva MN;Grasso D;Suriani MD;Lavor TS;Itri R;Baptista MS;Tsubone TM
癌症被认为是一种与年龄有关的疾病，在未来10年内，它将成为全球最普遍的健康问题。虽然癌症治疗在过去几十年中有了显着的改善，但需要新的治疗概念来击败这种疾病。光动力学疗法（PDT）是治疗和管理几种类型癌症的一种途径。在过去的三十年里，新的光源和光敏剂（PS）已被开发用于PDT。然而，目前缺乏知识来解释触发调节性细胞死亡机制所需的主要生化途径，这在很大程度上影响了PDT的范围。虽然自噬调节被提出作为一个有趣的策略，用于癌症治疗，主要方面是指细胞屈服PDT光诱导的损伤的自噬作用仍然难以捉摸。一些报道强调细胞保护性自噬，作为细胞科普光诱导的应激和生存的最终尝试。此外，还考虑了引起肿瘤细胞PDT抗性的其他潜在分子机制。本文综述了PDT调控的细胞死亡机制，包括自噬损伤或激活增强。为了包含治疗癌症的自噬靶向PDT方案，强调了减轻或增强肿瘤细胞的PDT抗性的那些方案。因此，这篇综述提供了对PDT可用于调节自噬的机制的见解，并强调了这一领域是如何代表一种有前途的癌症治疗策略的。
Cancer is considered an age-related disease that, over the next 10 years, will become the most prevalent health problem worldwide. Although cancer therapy has remarkably improved in the last few decades, novel treatment concepts are needed to defeat this disease. Photodynamic Therapy (PDT) signalize a pathway to treat and manage several types of cancer. Over the past three decades, new light sources and photosensitizers (PS) have been developed to be applied in PDT. Nevertheless, there is a lack of knowledge to explain the main biochemical routes needed to trigger regulated cell death mechanisms, affecting, considerably, the scope of the PDT. Although autophagy modulation is being raised as an interesting strategy to be used in cancer therapy, the main aspects referring to the autophagy role over cell succumbing PDT-photoinduced damage remain elusive. Several reports emphasize cytoprotective autophagy, as an ultimate attempt of cells to cope with the photo-induced stress and to survive. Moreover, other underlying molecular mechanisms that evoke PDT-resistance of tumor cells were considered. We reviewed the paradigm about the PDT-regulated cell death mechanisms that involve autophagic impairment or boosted activation. To comprise the autophagy-targeted PDT-protocols to treat cancer, it was underlined those that alleviate or intensify PDT-resistance of tumor cells. Thereby, this review provides insights into the mechanisms by which PDT can be used to modulate autophagy and emphasizes how this field represents a promising therapeutic strategy for cancer treatment.
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影响因子：
5.6
作者：
Bacellar IO;Tsubone TM;Pavani C;Baptista MS
通讯作者：
Baptista MS
影响因子：
6.1
作者：
Cozzolino, Marco;Delcanale, Pietro;Viappiani, Cristiano
通讯作者：
Viappiani, Cristiano
影响因子：
3.3
作者：
Bacellar, Isabel O. L.;Pavani, Christiane;Baptista, Mauricio S.
通讯作者：
Baptista, Mauricio S.
影响因子：
9.7
作者：
Baglo, Yan;Liang, Barry J.;Huang, Huang-Chian
通讯作者：
Huang, Huang-Chian
影响因子：
3.3
作者：
Baptista, MS;Indig, GL
通讯作者：
Indig, GL