Eco-evolutionary feedbacks in the human gut microbiome.
Eco-evolutionary feedbacks in the human gut microbiome.
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DOI：
10.1038/s41467-023-42769-3
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发表时间：
2023-11-06
影响因子：
16.6
通讯作者：
Rosenfeld, Layton B.
中科院分区：
文献类型：
--
作者：
Good, Benjamin H.;Rosenfeld, Layton B.
肠道微生物群可以在与人类相关的时间尺度上在宿主体内进化，但人们对这些变化如何影响（或受其影响）当地社区的组成知之甚少。在这里，通过结合对大量人类肠道宏基因组的生态和进化分析，我们表明微生物群的短期进化与其生态结构的变化有关。这些相关性不能简单地用进化物种的扩张来解释，而且往往涉及远亲类群的额外波动。我们发现，类似的反馈自然出现在简单的资源竞争模型，即使在没有交叉喂养或捕食。这些结果表明，宿主微生物群的结构和功能可能是由其局部进化历史塑造的，这可能对个性化医疗和微生物组工程具有重要意义。关于肠道微生物群的进化如何受到周围社区的影响，人们知之甚少。在这里，作者研究了人类肠道微生物组的进化生态学，模拟了资源竞争，以表明局部进化历史可以影响宿主微生物群的结构和功能。
Gut microbiota can evolve within their hosts on human-relevant timescales, but little is known about how these changes influence (or are influenced by) the composition of their local community. Here, by combining ecological and evolutionary analyses of a large cohort of human gut metagenomes, we show that the short-term evolution of the microbiota is linked with shifts in its ecological structure. These correlations are not simply explained by expansions of the evolving species, and often involve additional fluctuations in distantly related taxa. We show that similar feedbacks naturally emerge in simple resource competition models, even in the absence of cross-feeding or predation. These results suggest that the structure and function of host microbiota may be shaped by their local evolutionary history, which could have important implications for personalized medicine and microbiome engineering. Little is known about how the evolution of gut microbiota is impacted by their surrounding community. Here, the authors examine the evolutionary ecology of the human gut microbiome, modelling resource competition to show that local evolutionary history can impact the structure and function of host microbiota.
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