Future possibilities in the prevention of breast cancer: role of genetic variation in breast cancer prevention.

Future possibilities in the prevention of breast cancer: role of genetic variation in breast cancer prevention.
复制标题

预防乳腺癌的未来可能性:遗传变异在预防乳腺癌中的作用。

DOI:
10.1186/bcr69
复制
发表时间:
2000
期刊:
Breast cancer research : BCR
影响因子:
--
通讯作者:
Henderson BE
Henderson BE
中科院分区:
其他
文献类型:
--
作者:
Feigelson HS;Henderson BE

文献摘要

参考文献

被引文献

相似文献

乳腺癌的危险因素与内源性激素和生殖事件有关。因此,传统的癌症预防策略并不容易应用。他莫昔芬和其他选择性雌激素受体调节剂(SERM)为一些高危女性提供了一种新的预防策略,但尚未被证明对所有女性有效。需要新的工具来识别高风险女性。其中一种工具是开发乳腺癌易感性多基因模型,该模型可用于筛查女性,以识别携带使她们面临显着增加风险的等位基因组合的女性。
Risk factors for breast cancer are related to endogenous hormonesand reproductive events. As such, traditional cancer prevention strategies arenot easily applicable. Tamoxifen and other selective estrogen receptormodulators (SERMs) offer a new preventive strategy for some high-risk women,but have not yet been shown to be efficacious for all women. New tools toidentify high-risk women are needed. One such tool is the development of amultigenic model of breast cancer susceptibility that can be used to screenwomen in order to identify those who carry a combination of alleles that putsthem at significantly increased risk.
DOI: 10.1001/jama.281.23.2189
发表时间: 1999-06-16
影响因子: 120.7
作者:
Cummings, SR;Eckert, S;Jordan, VC
通讯作者: Jordan, VC
DOI: 10.1038/bjc.1998.340
发表时间: 1998-06
影响因子: 8.8
作者:
Dunning, A M;Healey, C S;Pharoah, P D;Foster, N A;Lipscombe, J M;Redman, K L;Easton, D F;Day, N E;Ponder, B A
通讯作者: Ponder, B A
DOI: 10.1093/hmg/3.10.1873
发表时间: 1994-10-01
影响因子: 3.5
作者:
CAREY, AH;WATERWORTH, D;WILLIAMSON, R
通讯作者: WILLIAMSON, R
DOI: 10.1093/jnci/91.21.1829
发表时间: 1999-11-03
期刊: JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子: --
作者:
Gail, MH;Costantino, JP;Vogel, V
通讯作者: Vogel, V
DOI: 10.1210/mend-4-12-1972
发表时间: 1990-12-01
影响因子: --
作者:
BRENTANO, ST;PICADOLEONARD, J;MILLER, WL
通讯作者: MILLER, WL