Biomarker progressions explain higher variability in stage-specific cognitive decline than baseline values in Alzheimer disease.
Biomarker progressions explain higher variability in stage-specific cognitive decline than baseline values in Alzheimer disease.
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DOI：
10.1016/j.jalz.2014.04.513
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Dodge HH;Zhu J;Harvey D;Saito N;Silbert LC;Kaye JA;Koeppe RA;Albin RL;Alzheimer's Disease Neuroimaging Initiative
目前尚不清楚哪种常用的阿尔茨海默病生物标志物值——基线值还是进展值——最能预测纵向认知能力下降。来自阿尔茨海默病神经影像学倡议的526名受试者。ADNI复合记忆（ADNI- mem）和执行（ADNI- exe）评分是主要指标。首先估计每个生物标志物纵向轨迹的个体特异性斜率。这些估计值和观察到的基线生物标志物值被用作认知能力下降的预测指标。将基线生物标志物值解释的认知衰退变异性与生物标志物进展值解释的变异性进行比较。大约40%的记忆变异性和执行功能下降可以用MCI患者的心室容积增加来解释。在AD患者中，84%的记忆力下降和65%的执行功能下降分别可以用FDG-PET评分进展和心室容积进展来解释。生物标志物进展解释了认知能力下降比生物标志物基线值更高的变异性。这对靶向修饰AD生物标志物的临床试验具有重要意义。
It is unknown which commonly employed Alzheimer disease biomarker values-baseline or progression-best predict longitudinal cognitive decline. 526 subjects from the Alzheimer’s Disease Neuroimaging Initiative. ADNI composite memory (ADNI-Mem) and executive (ADNI-Exe) scores were the primary outcomes. Individual-specific slope of the longitudinal trajectory of each biomarker was first estimated. These estimates and observed baseline biomarker values were used as predictors of cognitive declines. Variability in cognitive declines explained by baseline biomarker values were compared with variability explained by biomarker progression values. About 40% of variability in memory and executive function declines was explained by ventricular volume progression among MCI. 84% of memory and 65% of executive function declines were explained by FDG-PET score progression and ventricular volume progression, respectively, among AD. Biomarker progressions explained higher variability in cognitive decline than biomarker baseline values. This has important implications for clinical trials targeted to modify AD biomarkers.
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影响因子：
11.2
作者：
Landau, Susan M.;Mintun, Mark A.;Joshi, Abhinay D.;Koeppe, Robert A.;Petersen, Ronald C.;Aisen, Paul S.;Weiner, Michael W.;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
3.2
作者：
Crane, Paul K.;Carle, Adam;Gibbons, Laura E.;Insel, Philip;Mackin, R. Scott;Gross, Alden;Jones, Richard N.;Mukherjee, Shubhabrata;Curtis, S. McKay;Harvey, Danielle;Weiner, Michael;Mungas, Dan
通讯作者：
Mungas, Dan
影响因子：
9.9
作者：
Silbert, Lisa C.;Howieson, Diane B.;Kaye, Jeffrey A.
通讯作者：
Kaye, Jeffrey A.
DOI：
10.1016/j.jalz.2010.03.003
发表时间：
2010-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jagust WJ;Bandy D;Chen K;Foster NL;Landau SM;Mathis CA;Price JC;Reiman EM;Skovronsky D;Koeppe RA;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
8.3
作者：
Longstreth, WT;Arnold, AM;Furberg, CD
通讯作者：
Furberg, CD