Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
Development and assessment of a composite score for memory in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
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DOI：
10.1007/s11682-012-9186-z
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发表时间：
2012-12
影响因子：
3.2
通讯作者：
Mungas, Dan
中科院分区：
文献类型：
--
作者：
Crane, Paul K.;Carle, Adam;Gibbons, Laura E.;Insel, Philip;Mackin, R. Scott;Gross, Alden;Jones, Richard N.;Mukherjee, Shubhabrata;Curtis, S. McKay;Harvey, Danielle;Weiner, Michael;Mungas, Dan
我们试图开发和评估阿尔茨海默病（AD）神经影像倡议（ADNI）中使用的神经心理学组合的综合记忆评分。我们使用现代心理测量学方法分析纵向Rey听觉言语学习测试（RAVLT，2个版本），AD评估量表-认知（ADAS-Cog，3个版本），简易精神状态检查（MMSE）和逻辑记忆数据，以开发ADNI-Mem，一个复合记忆评分。我们比较了RAVLT和ADAS-Cog版本，并比较了ADNI-Mem与AVLT回忆总分、4个ADAS-Cog衍生评分、MMSE和临床痴呆评定总分。我们评估了正常认知、轻度认知障碍（MCI）和AD的下降率，预测从MCI向AD转化的能力，与选定成像参数的关联强度，以及区分有和无AD脑脊液（CSF）签名的参与者之间下降率的能力。第二个版本的RAVLT比第一个更难。ADAS-Cog版本具有类似的难度。ADNI-Mem在检测变化方面略优于总RAVLT回忆分数。在预测从MCI到AD的转换方面，它与所有其他评分一样好或更好。它与我们为MCI和AD患者选择的所有成像参数相关。具有AD CSF特征的MCI参与者比没有AD CSF特征的MCI参与者下降得更快。本文阐述了适当的方法来解决不同版本的单词列表，并展示了额外的权力收集与心理测量的声音复合记忆分数。
We sought to develop and evaluate a composite memory score from the neuropsychological battery used in the Alzheimer’s Disease (AD) Neuroimaging Initiative (ADNI). We used modern psychometric approaches to analyze longitudinal Rey Auditory Verbal Learning Test (RAVLT, 2 versions), AD Assessment Schedule - Cognition (ADAS-Cog, 3 versions), Mini-Mental State Examination (MMSE), and Logical Memory data to develop ADNI-Mem, a composite memory score. We compared RAVLT and ADAS-Cog versions, and compared ADNI-Mem to AVLT recall sum scores, four ADAS-Cog-derived scores, the MMSE, and the Clinical Dementia Rating Sum of Boxes. We evaluated rates of decline in normal cognition, mild cognitive impairment (MCI), and AD, ability to predict conversion from MCI to AD, strength of association with selected imaging parameters, and ability to differentiate rates of decline between participants with and without AD cerebrospinal fluid (CSF) signatures. The second version of the RAVLT was harder than the first. The ADAS-Cog versions were of similar difficulty. ADNI-Mem was slightly better at detecting change than total RAVLT recall scores. It was as good as or better than all of the other scores at predicting conversion from MCI to AD. It was associated with all our selected imaging parameters for people with MCI and AD. Participants with MCI with an AD CSF signature had somewhat more rapid decline than did those without. This paper illustrates appropriate methods for addressing the different versions of word lists, and demonstrates the additional power to be gleaned with a psychometrically sound composite memory score.
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影响因子：
--
作者：
De Meyer, Geert;Shapiro, Fred;Vanderstichele, Hugo;Vanmechelen, Eugeen;Engelborghs, Sebastiaan;De Deyn, Peter Paul;Coart, Els;Hansson, Oskar;Minthon, Lennart;Zetterberg, Henrik;Blennow, Kaj;Shaw, Leslie;Trojanowski, John Q.
通讯作者：
Trojanowski, John Q.
影响因子：
5.7
作者：
Walhovd, K. B.;Fjell, A. M.;Fladby, T.
通讯作者：
Fladby, T.
阿尔茨海默病神经影像计划的磁共振成像核心的最新信息。
影响因子：
14
作者：
Jack, Clifford R., Jr.;Bernstein, Matt A.;Borowski, Bret J.;Gunter, Jeffrey L.;Fox, Nick C.;Thompson, Paul M.;Schuff, Norbert;Krueger, Gunnar;Killiany, Ronald J.;DeCarli, Charles S.;Dale, Anders M.;Carmichael, Owen W.;Tosun, Duygu;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
影响因子：
5.7
作者：
Murphy, E. A.;Holland, D.;Donohue, M.;McEvoy, L. K.;Hagler, D. J., Jr.;Dale, A. M.;Brewer, J. B.
通讯作者：
Brewer, J. B.
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM