T follicular helper cells in germinal center B cell selection and lymphomagenesis.
T follicular helper cells in germinal center B cell selection and lymphomagenesis.
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DOI：
10.1111/imr.12860
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发表时间：
2020-07
影响因子：
8.7
通讯作者：
Cyster JG
中科院分区：
文献类型：
--
作者：
Mintz MA;Cyster JG
生发中心(GCs)是一种有限的解剖区域，在这里快速增殖的B细胞经历体细胞突变和选择，并最终分化为记忆B细胞或长寿的浆细胞。GCS也是恶性肿瘤的起源，即滤泡性淋巴瘤(FL)、GC B细胞弥漫性大B细胞淋巴瘤(GCB-DBLCL)和Burkitt淋巴瘤(BL)。GC B细胞淋巴瘤保持其GC转录特征，并维持GC微环境的许多特征，包括CD4+T滤泡辅助细胞(TFH)。TFH细胞对GCs的形成和维持是必不可少的，提供CD40L等关键的辅助信号。大规模的测序工作使人们对GC B细胞淋巴瘤发生过程中通常针对的严格调控的选择机制有了新的见解。例如，Hvem是一种在GC来源的淋巴瘤中频繁突变的表面分子，它与Tfh细胞上的抑制性受体BTLA结合，而Hvem的丢失会导致T细胞的夸大帮助。在这里，我们回顾了目前对TFH细胞如何对GC B细胞的选择做出贡献的理解，特别强调了TFH细胞信号如何可能有助于淋巴瘤的发生。讨论了靶向TfH细胞治疗GC来源的淋巴瘤的可能性。
Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long-lived plasma cells. GCs are also the origin of malignancy, namely follicular lymphoma (FL), GC B cell-diffuse large B cell lymphoma (GCB-DBLCL), and Burkitt lymphoma (BL). GC B cell lymphomas maintain their GC transcriptional signatures and sustain many features of the GC microenvironment, including CD4+ T follicular helper (Tfh) cells. Tfh cells are essential for the formation and maintenance of GCs, providing critical helper signals such as CD40L. Large scale sequencing efforts have led to new insights about the tightly regulated selection mechanisms that are commonly targeted during GC B cell lymphomagenesis. For instance, HVEM, a frequently mutated surface molecule in GC-derived lymphomas, engages the inhibitory receptor BTLA on Tfh cells and loss of HVEM leads to exaggerated T cell help. Here we review current understanding of how Tfh cells contribute to the selection of GC B cells, with a particular emphasis on how Tfh cell signals may contribute to lymphomagenesis. The possibility of targeting Tfh cells for the treatment of GC-derived lymphomas is discussed.
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DOI：
10.4049/jimmunol.0902490
发表时间：
2009-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cheung TC;Oborne LM;Steinberg MW;Macauley MG;Fukuyama S;Sanjo H;D'Souza C;Norris PS;Pfeffer K;Murphy KM;Kronenberg M;Spear PG;Ware CF
通讯作者：
Ware CF
影响因子：
50.3
作者：
Cortes JR;Ambesi-Impiombato A;Couronné L;Quinn SA;Kim CS;da Silva Almeida AC;West Z;Belver L;Martin MS;Scourzic L;Bhagat G;Bernard OA;Ferrando AA;Palomero T
通讯作者：
Palomero T
影响因子：
4.4
作者：
Chemnitz, JM;Parry, RV;Riley, JL
通讯作者：
Riley, JL
影响因子：
3.7
作者：
Auguste T;Travert M;Tarte K;Amé-Thomas P;Artchounin C;Martin-Garcia N;de Reynies A;de Leval L;Gaulard P;Delfau-Larue MH
通讯作者：
Delfau-Larue MH
淋巴瘤中HVEM肿瘤抑制剂的丧失和修饰的CAR-T细胞恢复。
影响因子：
64.5
作者：
Boice M;Salloum D;Mourcin F;Sanghvi V;Amin R;Oricchio E;Jiang M;Mottok A;Denis-Lagache N;Ciriello G;Tam W;Teruya-Feldstein J;de Stanchina E;Chan WC;Malek SN;Ennishi D;Brentjens RJ;Gascoyne RD;Cogné M;Tarte K;Wendel HG
通讯作者：
Wendel HG