Effects of angiotensin II receptor antagonists on insulin resistance syndrome and leptin in sucrose-fed spontaneously hypertensive rats.
Effects of angiotensin II receptor antagonists on insulin resistance syndrome and leptin in sucrose-fed spontaneously hypertensive rats.
复制标题
血管紧张素 II 受体拮抗剂对蔗糖喂养的自发性高血压大鼠胰岛素抵抗综合征和瘦素的影响。
DOI：
10.1291/hypres.26.485
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Murakami
中科院分区：
文献类型：
--
作者：
M. Umeda;T. Kanda;M. Murakami
为了探讨血管紧张素II型1受体（AT1）拮抗剂（ARA）在治疗高血压合并胰岛素抵抗综合征中的作用，我们研究了高剂量蔗糖饮食和ARA对自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）胰岛素敏感性、血浆脂质和瘦素的影响。SHR和WKY被分成三组，分别饲喂标准饲料、富含蔗糖的饲料或富含蔗糖的饲料和ARA，治疗12周。虽然在SHR中，高蔗糖饲料喂养的动物皮下和肠系膜脂肪组织的重量大于标准饲料喂养的动物，但ARA处理显著降低了皮下和肠系膜脂肪组织的重量。ARA治疗降低了SHR的游离脂肪酸和甘油三酯，增加了SHR和WKY的高密度脂蛋白胆固醇。体内平衡模型评估-胰岛素抵抗（HOMA-IR）指数、血浆瘦素水平和肠系膜脂肪组织中瘦素mRNA水平在富蔗糖饲料喂养的动物中显著高于标准饲料喂养的动物，而在SHR和WKY中，ara处理的富蔗糖饲料喂养的动物显著低于富蔗糖饲料喂养的动物。ARA改善胰岛素抵抗，降低血浆瘦素和脂肪组织中瘦素mRNA。这些结果表明，ARA对胰岛素抵抗的改善可能至少部分归因于脂肪组织重量的减少。结论ARA在高血压合并胰岛素抵抗综合征患者的治疗中是有用的。
In order to investigate the usefulness of angiotensin II type 1 receptor (AT1) antagonists (ARA) in the treatment of hypertension with insulin resistance syndrome, we studied the effects of a high dose sucrose diet and ARA on insulin sensitivity, plasma lipids, and leptin in spontaneous hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). SHR and WKY were divided into three groups and treated for 12 weeks: those fed a standard chow, those given a sucrose-rich chow or those given a sucrose-rich chow and ARA. While in SHR the weight of both subcutaneous and mesenteric adipose tissue was greater in the sucrose-rich chow fed animals than in the standard chow fed animals, ARA treatment significantly decreased the weights of both subcutaneous and mesenteric adipose tissue. ARA treatment decreased free fatty acid and triglyceride in SHR, and increased high density lipoprotein cholesterol in SHR and WKY. Homeostasis model assessment-insulin resistance (HOMA-IR) index, plasma levels of leptin, and leptin mRNA in mesenteric adipose tissue were significantly greater in the sucrose-rich chow fed animals than in the standard chow fed animals, and significantly lower in the ARA-treated sucrose-rich chow fed animals than in the sucrose-rich chow fed animals in both SHR and WKY. ARA improved insulin resistance, and reduced plasma leptin and leptin mRNA in adipose tissue. These results suggest that the improvement of insulin resistance by ARA may be attributed, at least in part, to the reduction of adipose tissue weight. It is concluded that ARA is useful in the treatment of patients with hypertension and concomitant insulin resistance syndrome.
影响因子：
7.7
作者：
Ebihara, K;Ogawa, Y;Nakao, K
通讯作者：
Nakao, K
蔗糖不会升高维持低盐摄入量的大鼠的血压。
DOI：
10.1161/01.hyp.21.6.779
发表时间：
1993
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Johnson,MD;Zhang,HY;Kotchen,TA
通讯作者：
Kotchen,TA
自发性高血压大鼠肾血管紧张素 II 亚型 1 受体反应增强。
DOI：
10.1161/01.hyp.21.4.420
发表时间：
1993
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
KostJr,CK;Jackson,EK
通讯作者：
Jackson,EK