Sucrose does not raise blood pressure in rats maintained on a low salt intake.
Sucrose does not raise blood pressure in rats maintained on a low salt intake.
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蔗糖不会升高维持低盐摄入量的大鼠的血压。
DOI：
10.1161/01.hyp.21.6.779
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kotchen,TA
中科院分区：
文献类型：
--
作者：
Johnson,MD;Zhang,HY;Kotchen,TA
其他研究表明，高蔗糖或果糖的饮食可以引起大鼠血压的适度升高。本实验旨在确定蔗糖引起的血压升高是否依赖于氯化钠的摄入。Sprague-Dawley的四组老鼠进行了研究:1)一组保持低盐饮食和蒸馏水(0.45%氯化钠,不添加蔗糖),2)低salt-high蔗糖组(0.45%氯化钠饮食和7%蔗糖在蒸馏水),3)高盐组(4%氯化钠饮食和蒸馏水),和4)高salt-high蔗糖组节食调整日常维护相同的高摄入量的氯化钠和蔗糖的组2和3。在治疗第1-3周用尾袖容积描记仪测量收缩压，在第4周记录清醒动物的直接平均动脉血压。高盐饮食的动物比低盐饮食的动物增重慢。在低氯化钠摄入量组，血压不受高饮食蔗糖的影响（1组与2组）。相比之下，在摄入大量氯化钠的情况下，饮用蔗糖的动物的血压比饮用水的动物高10-14毫米汞柱（第3组与第4组）。与单独摄入高氯化钠的动物相比，高氯化钠高蔗糖组的血压升高并没有伴随着更大的体重增加。（摘要删节250字）
Diets high in sucrose or fructose have been shown by others to induce a modest elevation of blood pressure in rats. The present experiments were conducted to determine whether the sucrose-induced increase of blood pressure is dependent on the intake of sodium chloride. Four groups of Sprague-Dawley rats were studied: 1) a group maintained on a low salt diet and distilled water (0.45% sodium chloride, no added sucrose), 2) a low salt-high sucrose group (0.45% sodium chloride diet and 7% sucrose in distilled water), 3) a high salt group (4% sodium chloride diet and distilled water), and 4) a high salt-high sucrose group on a diet adjusted daily to maintain the same high intakes of sodium chloride and sucrose as those of groups 2 and 3. Systolic blood pressures were measured by tail-cuff plethysmography during weeks 1-3 of treatment, and direct mean arterial blood pressures were recorded in conscious animals during week 4. Animals on the high salt diet gained weight more slowly than those on the low salt intake. On the low sodium chloride intake, blood pressures were not affected by high dietary sucrose (group 1 versus 2). In contrast, on the high sodium chloride intake, blood pressures were 10-14 mm Hg higher in sucrose-drinking animals than in water-drinking animals (group 3 versus 4). The increments in blood pressures of the high sodium chloride-high sucrose group were not accompanied by greater increments in body weight compared with the animals on the high sodium chloride intake alone.(ABSTRACT TRUNCATED AT 250 WORDS)
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DOI：
10.3181/00379727-123-31491
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影响因子：
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期刊：
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