Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis.
Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis.
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在一般人群中，葡萄糖-葡萄糖指数与心血管疾病风险和死亡率之间的关系：一项系统综述和荟萃分析
DOI：
10.1186/s12933-022-01546-0
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发表时间：
2022-07-01
影响因子：
9.3
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中科院分区：
文献类型：
--
作者：
胰岛素-葡萄糖（TyG）指数是一种新的胰岛素抵抗的替代措施。这项荟萃分析旨在评估TyG指数与一般人群心血管疾病风险和死亡率的相关性。检索PubMed、科克伦图书馆和Embase数据库中报告TyG指数与心血管疾病和死亡率相关性的随机对照试验或观察性队列研究（从开始到2022年4月16日）。使用随机效应模型合并效应量。稳健的误差元回归方法被应用于拟合非线性剂量-反应关系。使用建议分级评估、开发和评价系统（GRADE）评估证据质量水平和建议。本荟萃分析纳入了12项队列研究（6项前瞻性队列和6项回顾性队列），涉及6，354，990例受试者。与最低TyG指数类别相比，最高TyG指数与更高的冠状动脉疾病（CAD）发生率相关（3项研究;风险比[HR] = 2.01; 95%置信区间[CI] 1.68-2.40; I2 = 0%），心肌梗死（MI）（2项研究; HR = 1.36; 95% CI 1.18-1.56; I2 = 35%）和复合心血管疾病（CVD）（5项研究; HR = 1.46; 95% CI 1.23-1.74; I2 = 82%）。然而，TyG指数与死亡率（心血管死亡率[3项研究; HR = 1.10; 95% CI 0.82-1.47; I2 = 76%]或全因死亡率[4项研究; HR = 1.08; 95% CI 0.92-1.27; I2 = 87%]）之间无相关性。在剂量反应分析中，TyG指数与CAD（P非线性= 0.3807）或CVD（P非线性= 0.0612）的风险呈线性相关。GRADE评估表明CVD、MI、心血管死亡率和全因死亡率的确定性非常低，CAD的确定性中等。根据我们目前的证据，在一般人群中，较高的TyG指数可能与CAD（中度确定性）、MI（极低确定性）和CVD（极低确定性）的发病率增加相关。TyG指数与CAD和复合CVD发病率存在潜在的线性相关性。需要进一步的前瞻性研究（特别是在非亚洲人中）来证实我们的发现。在线版本包含补充材料，可通过10.1186/s12933-022-01546-0获得。
The triglyceride-glucose (TyG) index is a new alternative measure for insulin resistance. This meta-analysis was conducted to assess the associations of the TyG index with the risks of cardiovascular diseases and mortality in the general population. The PubMed, Cochrane Library and Embase databases were searched for randomized controlled trials or observational cohort studies reporting associations of the TyG index with cardiovascular diseases and mortality from inception to April 16, 2022. Effect sizes were pooled using random-effects models. Robust error meta-regression methods were applied to fit nonlinear dose–response associations. Evidence quality levels and recommendations were assessed using the Grading of Recommendations Assessment, Development and Evaluation system (GRADE). Twelve cohort studies (6 prospective and 6 retrospective cohorts) involving 6,354,990 participants were included in this meta-analysis. Compared with the lowest TyG index category, the highest TyG index was related to a higher incidence of coronary artery disease (CAD) (3 studies; hazard ratio [HR] = 2.01; 95% confidence interval [CI] 1.68–2.40; I2 = 0%), myocardial infarction (MI) (2 studies; HR = 1.36; 95% CI 1.18–1.56; I2 = 35%), and composite cardiovascular disease (CVD) (5 studies; HR = 1.46; 95% CI 1.23–1.74; I2 = 82%). However, there was no association between the TyG index and mortality (cardiovascular mortality [3 studies; HR = 1.10; 95% CI 0.82–1.47; I2 = 76%] or all-cause mortality [4 studies; HR = 1.08; 95% CI 0.92–1.27; I2 = 87%]). In the dose–response analysis, there was a linear association of the TyG index with the risk of CAD (Pnonlinear = 0.3807) or CVD (Pnonlinear = 0.0612). GRADE assessment indicated very low certainty for CVD, MI, cardiovascular mortality and all-cause mortality, and moderate certainty for CAD. Based on our current evidence, a higher TyG index may be associated with an increased incidence of CAD (moderate certainty), MI (very low certainty) and CVD (very low certainty) in the general population. There is a potential linear association of the TyG index with CAD and the composite CVD incidence. Further prospective studies (especially in non-Asians) are needed to confirm our findings. The online version contains supplementary material available at 10.1186/s12933-022-01546-0.
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影响因子：
24
作者：
Anand, Dhakshinamurthy Vijay;Lim, Eric;Lahiri, Avijit
通讯作者：
Lahiri, Avijit
影响因子：
9.3
作者：
Hu, Chengping;Zhang, Jianwei;Zhao, Yingxin
通讯作者：
Zhao, Yingxin
影响因子：
3.8
作者：
Kurl, Sudhir;Zaccardi, Francesco;Laukkanen, Jari A.
通讯作者：
Laukkanen, Jari A.
影响因子：
3.9
作者：
Cho YK;Lee J;Kim HS;Kim EH;Lee MJ;Yang DH;Kang JW;Jung CH;Park JY;Kim HK;Lee WJ
通讯作者：
Lee WJ
影响因子：
30.8
作者：
Deloukas, Panos;Kanoni, Stavroula;Willenborg, Christina;Farrall, Martin;Assimes, Themistocles L.;Thompson, John R.;Ingelsson, Erik;Saleheen, Danish;Erdmann, Jeanette;Goldstein, Benjamin A.;Stirrups, Kathleen;Koenig, Inke R.;Cazier, Jean-Baptiste;Johansson, Asa;Hall, Alistair S.;Lee, Jong-Young;Willer, Cristen J.;Chambers, John C.;Esko, Tonu;Folkersen, Lasse;Goel, Anuj;Grundberg, Elin;Havulinna, Aki S.;Ho, Weang K.;Hopewell, Jemma C.;Eriksson, Niclas;Kleber, Marcus E.;Kristiansson, Kati;Lundmark, Per;Lyytikainen, Leo-Pekka;Rafelt, Suzanne;Shungin, Dmitry;Strawbridge, Rona J.;Thorleifsson, Gudmar;Tikkanen, Emmi;Van Zuydam, Natalie;Voight, Benjamin F.;Waite, Lindsay L.;Zhang, Weihua;Ziegler, Andreas;Absher, Devin;Altshuler, David;Balmforth, Anthony J.;Barroso, Ines;Braund, Peter S.;Burgdorf, Christof;Claudi-Boehm, Simone;Cox, David;Dimitriou, Maria;Do, Ron;Doney, Alex S. F.;El Mokhtari, NourEddine;Eriksson, Per;Fischer, Krista;Fontanillas, Pierre;Franco-Cereceda, Anders;Gigante, Bruna;Groop, Leif;Gustafsson, Stefan;Hager, Joerg;Hallmans, Goran;Han, Bok-Ghee;Hunt, Sarah E.;Kang, Hyun M.;Illig, Thomas;Kessler, Thorsten;Knowles, Joshua W.;Kolovou, Genovefa;Kuusisto, Johanna;Langenberg, Claudia;Langford, Cordelia;Leander, Karin;Lokki, Marja-Liisa;Lundmark, Anders;McCarthy, Mark I.;Meisinger, Christa;Melander, Olle;Mihailov, Evelin;Maouche, Seraya;Morris, Andrew D.;Mueller-Nurasyid, Martina;Nikus, Kjell;Peden, John F.;Rayner, N. William;Rasheed, Asif;Rosinger, Silke;Rubin, Diana;Rumpf, Moritz P.;Schaefer, Arne;Sivananthan, Mohan;Song, Ci;Stewart, Alexandre F. R.;Tan, Sian-Tsung;Thorgeirsson, Gudmundur;van der Schoot, C. Ellen;Wagner, Peter J.;Wells, George A.;Wild, Philipp S.;Yang, Tsun-Po;Amouyel, Philippe;Arveiler, Dominique;Basart, Hanneke;Boehnke, Michael;Boerwinkle, Eric;Brambilla, Paolo;Cambien, Francois;Cupples, Adrienne L.;de Faire, Ulf;Dehghan, Abbas;Diemert, Patrick;Epstein, Stephen E.;Evans, Alun;Ferrario, Marco M.;Ferrieres, Jean;Gauguier, Dominique;Go, Alan S.;Goodall, Alison H.;Gudnason, Villi;Hazen, Stanley L.;Holm, Hilma;Iribarren, Carlos;Jang, Yangsoo;Kahonen, Mika;Kee, Frank;Kim, Hyo-Soo;Klopp, Norman;Koenig, Wolfgang;Kratzer, Wolfgang;Kuulasmaa, Kari;Laakso, Markku;Laaksonen, Reijo;Lee, Ji-Young;Lind, Lars;Ouwehand, Willem H.;Parish, Sarah;Park, Jeong E.;Pedersen, Nancy L.;Peters, Annette;Quertermous, Thomas;Rader, Daniel J.;Salomaa, Veikko;Schadt, Eric;Shah, Svati H.;Sinisalo, Juha;Stark, Klaus;Stefansson, Kari;Tregouet, David-Alexandre;Virtamo, Jarmo;Wallentin, Lars;Wareham, Nicholas;Zimmermann, Martina E.;Nieminen, Markku S.;Hengstenberg, Christian;Sandhu, Manjinder S.;Pastinen, Tomi;Syvanen, Ann-Christine;Hovingh, G. Kees;Dedoussis, George;Franks, Paul W.;Lehtimaki, Terho;Metspalu, Andres;Zalloua, Pierre A.;Siegbahn, Agneta;Schreiber, Stefan;Ripatti, Samuli;Blankenberg, Stefan S.;Perola, Markus;Clarke, Robert;Boehm, Bernhard O.;O'Donnell, Christopher;Reilly, Muredach P.;Maerz, Winfried;Collins, Rory;Kathiresan, Sekar;Hamsten, Anders;Kooner, Jaspal S.;Thorsteinsdottir, Unnur;Danesh, John;Palmer, Colin N. A.;Roberts, Robert;Watkins, Hugh;Schunkert, Heribert;Samani, Nilesh J.
通讯作者：
Samani, Nilesh J.