Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study.
Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study.
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DOI：
10.3390/jcm10010092
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发表时间：
2020-12-29
影响因子：
3.9
通讯作者：
Lee WJ
中科院分区：
文献类型：
--
作者：
Cho YK;Lee J;Kim HS;Kim EH;Lee MJ;Yang DH;Kang JW;Jung CH;Park JY;Kim HK;Lee WJ
甘油三酯葡萄糖（TyG）指数是甘油三酯和空腹血糖的乘积，是胰岛素抵抗的可靠标志物。我们旨在研究TyG相关标志物与冠状动脉钙化（CAC）进展之间的关系。我们招募了1145名无症状的参与者，他们在常规健康检查期间重复进行CAC评分测量。计算胰岛素抵抗的稳态模型评估（HOMA-IR）、TyG指数、TyG-BMI（体重指数）和TyG-WC（腰围）。CAC进展定义为（1）无CAC人群中发生CAC，或（2）可检测到CAC的参与者中基线和CAC评分最终平方根之间增加≥2.5个单位。根据参数的四分位数，我们将受试者分为四组。进展的发生率随着TyG-WC四分位数的增加而增加（每组分别为15.0%、24.1%、31.0%和32.2%; p < 0.001）。当比较最高和最低TyG-WC指数四分位数时，CAC评分进展的多变量校正比值比（95%置信区间）为1.66（1.01-2.77）。此外，在曲线下面积方面，TyG-WC对CAC进展的预测性优于其他指标。TyG-WC指数预测CAC进展优于其他指数，可能是未来冠状动脉粥样硬化的潜在标志物。
The triglyceride glucose (TyG) index, a product of triglyceride and fasting glucose, is a reliable marker for insulin resistance. We aimed to investigate the association between the TyG-related markers and coronary artery calcification (CAC) progression. We enrolled 1145 asymptomatic participants who underwent repeated CAC score measurements during routine health examinations. Homeostasis model assessment of insulin resistance (HOMA-IR), TyG index, TyG-BMI (body mass index), and TyG-WC (waist circumference) were calculated. Progression of CAC was defined as (1) incident CAC in a CAC-free population, or an (2) increase of ≥2.5 units between the baseline and final square root of the CAC scores in participants with detectable CAC. According to the quartiles of parameters, we stratified the subjects into four groups. The prevalence of progression increased with the TyG-WC quartile (15.0%, 24.1%, 31.0%, and 32.2% for each of the groups; p < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for CAC score progression was 1.66 (1.01–2.77) when the highest and lowest TyG-WC index quartiles were compared. Furthermore, the predictability of TyG-WC for CAC progression was better than the other indices in terms of the area under the curve. The TyG-WC index predicted CAC progression better than other indices and could be a potential marker of future coronary atherosclerosis.
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影响因子：
16.2
作者：
Carson AP;Steffes MW;Carr JJ;Kim Y;Gross MD;Carnethon MR;Reis JP;Loria CM;Jacobs DR Jr;Lewis CE
通讯作者：
Lewis CE
影响因子：
3.7
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Ko YL
影响因子：
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Jung, Chang Hee;Lee, Min Jung;Lee, Woo Je
通讯作者：
Lee, Woo Je
影响因子：
120.7
作者：
Greenland, P;LaBree, L;Detrano, RC
通讯作者：
Detrano, RC
影响因子：
16.2
作者：
Blaha, Michael J.;DeFilippis, Andrew P.;Nasir, Khurram
通讯作者：
Nasir, Khurram