Structure and etiology of co-occurring internalizing and externalizing disorders in adolescents.
Structure and etiology of co-occurring internalizing and externalizing disorders in adolescents.
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青少年共同出现的内在化和外部化疾病的结构和病因。
DOI：
10.1007/s10802-010-9444-8
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发表时间：
2011-01
影响因子：
3.6
通讯作者：
Hewitt, John K.
中科院分区：
文献类型：
--
作者：
Cosgrove, Victoria E.;Rhee, Soo H.;Gelhorn, Heather L.;Boeldt, Debra;Corley, Robin C.;Ehringer, Marissa A.;Young, Susan E.;Hewitt, John K.
一些研究表明，内化和外化因素并存的双因素模型解释了精神障碍之间的相互关系。然而，尚不清楚内在性和外在性障碍之间的共同变异是由于共同的遗传还是环境影响。我们考察了假设内化和外化两个潜在因素的模型是否解释了青少年六种精神障碍(严重抑郁障碍、广泛性焦虑障碍、分离性焦虑障碍、注意缺陷/多动障碍、对立违抗障碍和品行障碍)之间的相互关系，以及是否存在共同的遗传和环境影响内化和外化潜在因素。对科罗拉多州反社会药物依赖中心(CADD)从普通人群中确认的1162对双胞胎和426个兄弟姐妹的数据进行了多变量行为遗传学分析。我们发现一个假设了两个潜在因素(内化和外化)的模型得到了支持。这些因素是适度可遗传的，并受到显著的共同的遗传和非共同的环境影响。这些发现表明，青少年内在性和外在性精神病理学的共同出现是遗传和环境影响的结果。
Several studies suggest that a two-factor model positing internalizing and externalizing factors explains the interrelationships among psychiatric disorders. However, it is unclear whether the covariation between internalizing and externalizing disorders is due to common genetic or environmental influences. We examined whether a model positing two latent factors, internalizing and externalizing, explained the interrelationships among six psychiatric disorders (major depressive disorder, generalized anxiety disorder, separation anxiety disorder, attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder) in adolescents, and whether there are common genetic and environmental influences on internalizing and externalizing latent factors. Multivariate behavior genetic analyses of data from 1162 twin pairs and 426 siblings ascertained from the general population via the Colorado Center for Antisocial Drug Dependence (CADD) were conducted. We found support for a model positing two latent factors (internalizing and externalizing). These factors were moderately heritable and influenced by significant common genetic and nonshared environmental influences. These findings suggest that co-occurrence of internalizing and externalizing psychopathology in adolescents results from both genetic and environmental influences.
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DOI：
10.1375/1369052042663832
发表时间：
2004-12-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Derks, EM;Dolan, CV;Boomsma, DI
通讯作者：
Boomsma, DI
影响因子：
4.6
作者：
Hicks, Brian M.;Blonigen, Daniel M.;Mcgue, Matt
通讯作者：
Mcgue, Matt
影响因子：
2.6
作者：
HEWITT, JK;SILBERG, JL;ERICKSON, M
通讯作者：
ERICKSON, M
影响因子：
--
作者：
Kendler, KS;Prescott, CA;Neale, MC
通讯作者：
Neale, MC
影响因子：
3.1
作者：
Hudziak, James J.;Achenbach, Thomas M.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.