Association between male gender and cortical Lewy body pathology in large autopsy series.
Association between male gender and cortical Lewy body pathology in large autopsy series.
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DOI：
10.1007/s00415-010-5630-4
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发表时间：
2010-11
影响因子：
6
通讯作者：
Markesbery WR
中科院分区：
文献类型：
--
作者：
Nelson PT;Schmitt FA;Jicha GA;Kryscio RJ;Abner EL;Smith CD;Van Eldik LJ;Markesbery WR
性别相关因素可能会改变神经退行性疾病的风险。直到尸检才能做出明确的诊断，因此神经病理学研究至关重要。使用大型多中心尸检系列尚未报告新皮质路易体（LB）存在性别相关差异。我们评估了性别与病理特征神经退行性疾病之间的关联。患有阿尔茨海默病 (AD)、新皮质 LB、AD + 新皮质 LB 或两者均无病理的病例作为单独的组进行评估。结果针对可能的混杂因素进行了校正，包括死亡年龄、吸烟史和教育程度。地点是肯塔基大学阿尔茨海默病中心和国家阿尔茨海默病协调中心 (NACC) 登记尸检系列； 3,830 名受试者符合纳入标准。患有新皮质（“弥漫性”）或中间（“边缘”）LB 病变的患者往往是男性（男性：女性比值比 ~2.9，95% CI 2.02-4.18）。男性死于新皮质 LB 病理的比例在各个年龄组中都是一致的，并不是由于评估的潜在混杂因素造成的。相比之下，如果死亡时间超过 80 岁，死于 AD 病理的个体更有可能是女性（男性：女性比值比 0.66，95% CI 0.50-0.88），但这种趋势在 80 岁之前死于 AD 病理的个体中并未观察到。增加对新皮质 LB 病理中男性优势的了解可能有助于指导临床医生，因为男性更有可能在临床上“低估”新皮质 LB。女性更有可能被“夸大”（两者 P < 0.05）。男性死于新皮质 LB 病理的可能性远高于女性。这种现象可能有助于指导医学实践，包括临床试验研究设计。
Sex-linked factors may alter risk for neurodegenerative diseases. Definitive diagnoses are not established until autopsy, so neuropathological studies are critical. There have not been reported gender-related differences in neocortical Lewy bodies (LBs) using large multi-center autopsy series. We evaluated the associations between gender and pathologically characterized neurodegenerative diseases. Cases with Alzheimer's disease (AD), neocortical LBs, AD + neocortical LBs, or neither pathology were evaluated as separate groups. Results were corrected for possible confounders including age at death, smoking history, and education. The settings were the University of Kentucky Alzheimer's Disease Center and the National Alzheimer's Coordinating Center (NACC) Registry autopsy series; 3,830 subjects met inclusion criteria. Patients with neocortical (“diffuse”) or intermediate (“limbic”) LB pathologies tended to be male (male:female odds ratios ∼2.9 with 95% CI 2.02–4.18). The preponderance of males dying with neocortical LB pathology was seen consistently across age groups and was not due to the potential confounders evaluated. By contrast, individuals dying with AD pathology were more likely to be female if dying over 80 (male:female odds ratio 0.66, 95% CI 0.50–0.88), but that tendency was not seen in individuals dying with AD pathology prior to age 80. Increased understanding of the male predominance in neocortical LB pathology may help guide clinicians, because males are more likely to be “undercalled” for neocortical LBs clinically, and females are more likely to be “overcalled” (P < 0.05 for both). Males are far more likely than females to die with neocortical LB pathology. This phenomenon may help guide medical practice including clinical trial study design.
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影响因子：
9.9
作者：
Olichney, JM;Galasko, D;Thal, LJ
通讯作者：
Thal, LJ
DOI：
10.1111/j.1750-3639.2009.00296.x
发表时间：
2010-03
期刊：
Brain pathology (Zurich, Switzerland)
影响因子：
--
作者：
Tsuang D;Larson EB;Li G;Shofer JB;Montine KS;Thompson ML;Sonnen JA;Crane PK;Leverenz JB;Montine TJ
通讯作者：
Montine TJ
DOI：
10.1097/nen.0b013e31815c5efb
发表时间：
2007-12-01
影响因子：
3.2
作者：
Nelson, Peter T.;Jicha, Gregory A.;Markesbery, William R.
通讯作者：
Markesbery, William R.
影响因子：
6
作者：
Nelson PT;Jicha GA;Kryscio RJ;Abner EL;Schmitt FA;Cooper G;Xu LO;Smith CD;Markesbery WR
通讯作者：
Markesbery WR
影响因子：
--
作者：
Shulman, Lisa M.
通讯作者：
Shulman, Lisa M.