Association between lifetime cigarette smoking and lewy body accumulation.
Association between lifetime cigarette smoking and lewy body accumulation.
复制标题
DOI：
10.1111/j.1750-3639.2009.00296.x
复制
发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Montine TJ
中科院分区：
文献类型：
--
作者：
Tsuang D;Larson EB;Li G;Shofer JB;Montine KS;Thompson ML;Sonnen JA;Crane PK;Leverenz JB;Montine TJ
在观察性研究中，吸烟与帕金森病（PD）风险降低反复相关，但其与痴呆或阿尔茨海默病（AD）风险的关系不一致。所有这些研究都使用了疾病的临床诊断。我们在一项前瞻性的基于社区的脑老化和痴呆研究中，即成人思维变化（ACT）研究中，检验了以下假设：终生吸烟可能与多个脑区路易相关病理学（LRP）神经病理学变化风险降低或与AD共识神经病理学变化风险降低相关。我们观察到，在校正选择偏倚后，长期大量吸烟（> 50包年）与LRP的相对危险度（RR）显著降低相关，但与AD型病理变化无关，并且与黑质LRP的频率显著降低相关。这些研究结果是我们首次将人类大脑中LRP的降低与任何暴露联系起来，并证实了吸烟与PD风险降低相关的观察性研究。虽然吸烟毒性太大，不能作为一种治疗方法，但如果得到证实，这些发现可能会指导未来的治疗策略，试图通过其他手段抑制人脑中的LRP。
Cigarette smoking has been associated repeatedly in observational studies with decreased risk of Parkinson's disease (PD), but its relationship to the risk of dementia or Alzheimer's disease (AD) is inconsistent. All of these studies have used clinical diagnoses of disease. We tested the hypothesis that lifetime cigarette use might be associated with reduced risk of neuropathologic changes of Lewy-related pathology (LRP) in multiple brain regions or with reduced risk of consensus neuropathologic changes of AD in a prospective community-based study of brain aging and dementia, the Adult Changes in Thought (ACT) study. We observed that heavy lifetime cigarette smoking (> 50 pack years) was associated with significantly reduced relative risk (RR) for LRP, but not AD-type pathologic changes, after correcting for selection bias, and with significantly reduced frequency of LRP in the substantia nigra. These findings are the first of which we are aware to associate reduced LRP in human brain with any exposure, and substantiate observational studies that have associated cigarette smoking with reduced risk of PD. Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means.
登录
查看更多内容
影响因子：
5.3
作者：
Ono, Kenjiro;Hirohata, Mie;Yamada, Masahito
通讯作者：
Yamada, Masahito
影响因子：
6.4
作者：
Leverenz, James B.;Hamilton, Ronald;Montine, Thomas J.
通讯作者：
Montine, Thomas J.
影响因子：
--
作者：
Kasten M;Chade A;Tanner CM
通讯作者：
Tanner CM
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM
DOI：
10.1016/j.bbapap.2008.09.026
发表时间：
2009-02-01
影响因子：
3.2
作者：
Hong, Dong-Pyo;Fink, Anthony L.;Uversky, Vladimir N.
通讯作者：
Uversky, Vladimir N.