Role of Innate T Cells in Anti-Bacterial Immunity.
Role of Innate T Cells in Anti-Bacterial Immunity.
复制标题
DOI：
10.3389/fimmu.2015.00302
复制
发表时间：
2015
影响因子：
7.3
通讯作者：
Williams AP
中科院分区：
文献类型：
--
作者：
Gao Y;Williams AP
先天T细胞是一组异质的αβ和γδT细胞，激活后反应迅速(<；2 h)。这些与生俱来的T细胞也共享非MHC I或II类抗原识别限制要求。先天T细胞群中的三个主要群体被认为是不变的NKT细胞、粘膜相关的不变T细胞和Gamma Delta T细胞。这些细胞识别非经典MHC分子，如CD1d、MR1和CD1a所呈现的异体/自体脂质。它们在细菌感染的早期阶段被激活，并在先天免疫系统和获得性免疫系统之间起到桥梁作用。在这篇综述中，我们重点介绍了这三个先天T细胞群的功能特性以及它们是如何用于抗菌防御的。此外，我们阐述了它们的效应器功能针对细菌控制的机制，并在人类和小鼠系统中进行了比较。最后，我们推测这些细胞类型在疫苗接种等治疗环境中的未来作用。
Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (<2 h) upon activation. These innate T cells also share a non MHC class I or II restriction requirement for antigen recognition. Three major populations within the innate T cell group are recognized, namely, invariant NKT cells, mucosal associated invariant T cells, and gamma delta T cells. These cells recognize foreign/self-lipid presented by non-classical MHC molecules, such as CD1d, MR1, and CD1a. They are activated during the early stages of bacterial infection and act as a bridge between the innate and adaptive immune systems. In this review, we focus on the functional properties of these three innate T cell populations and how they are purposed for antimicrobial defense. Furthermore, we address the mechanisms through which their effector functions are targeted for bacterial control and compare this in human and murine systems. Lastly, we speculate on future roles of these cell types in therapeutic settings such as vaccination.
登录
查看更多内容
影响因子：
4.8
作者：
Espinosa, E;Belmant, C;Fournié, JJ
通讯作者：
Fournié, JJ
影响因子：
4.4
作者：
Collins, C;Wolfe, J;Budd, RC
通讯作者：
Budd, RC
影响因子：
3.1
作者：
Behr, C;Poupot, R;Fournie, JJ
通讯作者：
Fournie, JJ
影响因子：
3.5
作者：
Aggarwal, Ashish;Sharma, Aman;Bhatnagar, Archana
通讯作者：
Bhatnagar, Archana
影响因子：
4.3
作者：
Eguchi, Takanori;Kumagai, Kenichi;Suzuki, Ryuji
通讯作者：
Suzuki, Ryuji