Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice.
Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice.
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碧容健®通过载脂蛋白 E 缺陷小鼠的 PKA 信号通路诱导白色脂肪组织褐变。
DOI：
10.1155/2018/9713259
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发表时间：
2018
影响因子：
4.3
通讯作者：
Gu J
中科院分区：
文献类型：
--
作者：
Cong H;Zhong W;Wang Y;Ikuyama S;Fan B;Gu J
白色脂肪组织中的米色脂肪细胞(WAT)因其潜在的肥胖保护作用而受到相当大的重视。碧萝香酚(PYC)是从法国海洋松树皮中提取的，具有抗炎和抗氧化特性，并能改善血脂状况。然而，PYC对肥胖的影响从未被探索过。在这项研究中，我们研究了PYC对载脂蛋白E-(ApoE-)缺陷小鼠肥胖和Wat褐变的影响。结果表明，PYC治疗明显逆转了高胆固醇和高脂肪饮食(HCD)引起的体重和eWAT增加的质量，但在食物摄入量方面没有差异。形态学结果显示，PYC组小鼠的脂肪细胞明显小于HCD组小鼠。接下来，我们发现PYC上调了与脂解相关的基因(ATGL和HSL)的表达，而降低了PLIN1的mRNA水平。PYC显著上调UCP1等米色脂肪形成相关基因的表达。此外，PYC还增加了与蛋白激酶A(PKA)信号通路相关的蛋白质的表达。研究结果表明，PYC通过促进脂肪分解和Wat褐变来减轻肥胖。因此，PYC可能成为治疗肥胖症的新靶点。
Beige adipocytes in white adipose tissue (WAT) have received considerable recognition because of their potential protective effect against obesity. Pycnogenol (PYC), extracted from French maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. However, the effect of PYC on obesity has never been explored. In this study, we investigated the effects of PYC on obesity and WAT browning in apolipoprotein E- (ApoE-) deficient mice. The results showed that PYC treatment clearly reversed body weight and the mass of eWAT gain resulting from a high-cholesterol and high-fat diet (HCD), but no difference in food intake. The morphology results showed that the size of the adipocytes in the PYC-treated mice was obviously smaller than that in the HCD-fed mice. Next, we found that PYC upregulated the expression of genes related to lipolysis (ATGL and HSL), while it decreased the mRNA level of PLIN1. PYC significantly increased the expression of UCP1 and other genes related to beige adipogenesis. Additionally, PYC increased the expression of proteins related to the protein kinase A (PKA) signaling pathway. The findings suggested that PYC decreased obesity by promoting lipolysis and WAT browning. Thus, PYC may be a novel therapeutic target for obesity.
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影响因子：
16.6
作者：
Berbée JF;Boon MR;Khedoe PP;Bartelt A;Schlein C;Worthmann A;Kooijman S;Hoeke G;Mol IM;John C;Jung C;Vazirpanah N;Brouwers LP;Gordts PL;Esko JD;Hiemstra PS;Havekes LM;Scheja L;Heeren J;Rensen PC
通讯作者：
Rensen PC
DOI：
10.1016/j.bbalip.2009.04.002
发表时间：
2009-06
影响因子：
4.8
作者：
Bickel, Perry E.;Tansey, John T.;Welte, Michael A.
通讯作者：
Welte, Michael A.
影响因子：
4.8
作者：
Cao, WH;Medvedev, AV;Collins, S
通讯作者：
Collins, S
影响因子：
4.8
作者：
Haemmerle, G;Zimmermann, R;Zechner, R
通讯作者：
Zechner, R
影响因子：
4.3
作者：
Keipert, Susanne;Jastroch, Martin
通讯作者：
Jastroch, Martin