Saccade Suppression by Electrical Microstimulation in Monkey Caudate Nucleus
Saccade Suppression by Electrical Microstimulation in Monkey Caudate Nucleus
复制标题
猴尾状核电微刺激抑制眼跳
作者：
Masayuki Watanabe;D. Munoz
尾状核是基底神经节的输入区，根据其解剖学特点，尾状核可以促进和抑制眼跳的起始。虽然尾状核参与扫视促进先前已被证明，它仍然不清楚尾状核是否也参与扫视抑制。在这里，我们揭示了直接参与的尾状核眼跳抑制电微刺激行为的猴子。我们提供微刺激的尾状核，而猴子进行前视（看向周边视觉刺激）和反视（看远离刺激）的范例。对侧眼跳的反应时间在正眼跳和反眼跳试验中均延长。对反应时的抑制作用更强的正面实验相比，与antisaccade试验。反应时间分布的分析使用的线性方法与遍历率模型（LATER模型）阈值显示，微刺激延长反应时间，通过降低上升到阈值的眼跳启动率。微刺激也恶化了对侧扫视的正确执行率。同样的微刺激延长和/或缩短同侧扫视的反应时间，虽然效果并不一致，对侧扫视。我们的结论是，尾状核信号是足够的，以抑制对侧扫视和影响扫视决定，通过控制对侧和同侧扫视命令在同一时间。
It has been suggested that the caudate nucleus, the input stage of the basal ganglia, facilitates and suppresses saccade initiation based on its anatomical characteristics. Although the involvement of the caudate nucleus in saccade facilitation has been shown previously, it is still unclear whether the caudate nucleus is also involved in saccade suppression. Here, we revealed the direct involvement of the caudate nucleus in saccade suppression by electrical microstimulation in behaving monkeys. We delivered microstimulation to the caudate nucleus while monkeys performed the prosaccade (look toward a peripheral visual stimulus) and antisaccade (look away from the stimulus) paradigm. The reaction times of contralateral saccades were prolonged on both prosaccade and antisaccade trials. The suppression effects on reaction times were stronger on prosaccade trials compared with antisaccade trials. The analysis of reaction time distributions using the linear approach to threshold with ergodic rate model (LATER model) revealed that microstimulation prolonged reaction times by reducing the rate of rise to the threshold for saccade initiation. Microstimulation also worsened correct performance rates for contralateral saccades. The same microstimulation prolonged and/or shortened the reaction times of ipsilateral saccades, although the effects were not as consistent as those on contralateral saccades. We conclude that caudate signals are sufficient to suppress contralateral saccades and influence saccadic decision by controlling contralateral and ipsilateral saccade commands at the same time.
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影响因子：
2.5
作者：
NAMBU, A;LLINAS, R
通讯作者：
LLINAS, R
DOI：
--
发表时间：
1989
期刊：
Reviews of oculomotor research
影响因子：
--
作者：
D. Sparks;R. Hartwich-Young
通讯作者：
D. Sparks;R. Hartwich-Young
影响因子：
2.5
作者：
WICHMANN, T;BERGMAN, H;DELONG, MR
通讯作者：
DELONG, MR
影响因子：
2.5
作者：
DELONG, MR;CRUTCHER, MD;GEORGOPOULOS, AP
通讯作者：
GEORGOPOULOS, AP