Development of a novel mouth model as an alternative tool to test the effectiveness of an in vivo EPR dosimetry system.
Development of a novel mouth model as an alternative tool to test the effectiveness of an in vivo EPR dosimetry system.
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DOI：
10.1088/1361-6560/aad518
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发表时间：
2018-08-10
影响因子：
3.5
通讯作者：
Flood AB
中科院分区：
文献类型：
--
作者：
Kobayashi K;Dong R;Nicolalde RJ;Calderon P;Du G;Williams BB;Lee MC;Swartz HM;Flood AB
在大规模辐射事件中，数千人可能暴露在未知量的辐射中，其中一些可能在没有立即注意的情况下危及生命。在这种情况下，一种快速可靠地估计剂量的方法将有助于医疗响应人员对受害者进行分流，以获得拯救生命的护理。我们开发了一种使用电子顺磁共振(EPR)对上颌门牙进行活体测量的方法。这份报告提供的证据表明，使用体外研究可以提供完全代表体内测量结果的数据。这是必要的，因为为了系统地测试和提高使用我们的EPR剂量测量系统进行的剂量估计的可靠性和准确性，使用受辐射的人类牙齿进行体外对照研究是重要的。因此，必须验证我们的体外模型是否充分模拟了体内的测量，这些测量旨在帮助指导辐射事件后的分诊决策。使用一名健康的志愿者，牙列间隙允许使用部分义齿，在体外对人类牙齿进行连续照射，然后使用部分义齿，放入志愿者的口腔进行测量。我们将志愿者口腔中的活体测量结果与复杂口腔模型中相同牙齿的测量结果进行了比较，该模型模拟了口腔的电磁和解剖特性。我们的结果表明，这种口腔模型可以用于体外研究，以开发该系统，因为这些测量适合模拟体内条件。
In a large-scale radiation event, thousands may be exposed to unknown amounts of radiation, some of which may be life-threatening without immediate attention. In such situations, a method to quickly and reliably estimate dose would help medical responders triage victims to receive life-saving care. We developed such a method using electron paramagnetic resonance (EPR) to make in vivo measurements of the maxillary incisors. This report provides evidence that the use of in vitro studies can provide data that are fully representative of the measurements made in vivo. This is necessary because, in order to systematically test and improve the reliability and accuracy of the dose estimates made with our EPR dosimetry system, it is important to conduct controlled studies in vitro using irradiated human teeth. Therefore, it is imperative to validate whether our in vitro models adequately simulate the measurements made in vivo, which are intended to help guide decisions on triage after a radiation event. Using a healthy volunteer with a dentition gap that allows using a partial denture, human teeth were serially irradiated in vitro and then, using a partial denture, placed in the volunteer’s mouth for measurements. We compared dose estimates made using in vivo measurements made in the volunteer’s mouth to measurements made on the same teeth in our complex mouth model that simulates electromagnetic and anatomic properties of the mouth. Our results demonstrate that this mouth model can be used in in vitro studies to develop the system because these measurements appropriately model in vivo conditions.
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影响因子：
2.2
作者：
Sullivan JM;Prasanna PG;Grace MB;Wathen LK;Wallace RL;Koerner JF;Coleman CN
通讯作者：
Coleman CN
影响因子：
2.2
作者：
Salikhov, I;Hirata, H;Swartz, HM
通讯作者：
Swartz, HM
影响因子：
1.7
作者：
Williams, Benjamin B.;Flood, Ann Barry;Swartz, Harold M.
通讯作者：
Swartz, Harold M.
影响因子：
2.6
作者：
Williams BB;Dong R;Nicolalde RJ;Matthews TP;Gladstone DJ;Demidenko E;Zaki BI;Salikhov IK;Lesniewski PN;Swartz HM
通讯作者：
Swartz HM
影响因子：
1
作者：
Coleman, C. Norman;Koerner, John F.
通讯作者：
Koerner, John F.