Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells.
Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells.
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DOI：
10.1007/978-3-319-55947-6_15
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发表时间：
2017
影响因子：
--
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Wang D;Wu L;Liu X
We present here an experimental approach for exploring a new class of tumor biomarkers that are overexpressed by circulating tumor cells (CTCs) and are likely targetable in immunotherapy against tumor metastasis. Using carbohydrate microarrays, anti-tumor monoclonal antibodies (mAbs) were scanned against a large panel of carbohydrate antigens to identify potential tumor glycan markers. Subsequently, flow cytometry and fiber-optic array scanning technology (FAST) were applied to determine whether the identified targets are tumor-specific cell-surface markers and are, therefore, likely suitable for targeted immunotherapy. Finally, the tumor glycan-specific antibodies identified were validated using cancer patients’ blood samples for their performance in CTC-detection and immunotyping analysis. In this article, identifying breast CTC-specific glycan markers and targeting mAbs serve as examples to illustrate this tumor biomarker discovery strategy.
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影响因子：
6.2
作者：
Codington, JF;Haavik, S;Wu, ZB
通讯作者：
Wu, ZB
影响因子：
4
作者：
Hayashi, Naoki;Yamauchi, Hideko
通讯作者：
Yamauchi, Hideko
DOI：
10.1084/jem.133.1.39
发表时间：
1971-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Feizi T;Kabat EA;Vicari G;Anderson B;Marsh WL
通讯作者：
Marsh WL
影响因子：
3.8
作者：
Somlo, George;Lau, Sean K.;Frankel, Paul;Ben Hsieh, H.;Liu, Xiaohe;Yang, Lixin;Krivacic, Robert;Bruce, Richard H.
通讯作者：
Bruce, Richard H.
影响因子：
2.9
作者：
CODINGTON, JF;SANFORD, BH;JEANLOZ, RW
通讯作者：
JEANLOZ, RW