Akt Isoforms: A Family Affair in Breast Cancer.
Akt Isoforms: A Family Affair in Breast Cancer.
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DOI：
10.3390/cancers13143445
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发表时间：
2021-07-09
期刊：
影响因子：
5.2
通讯作者：
Lambring CB
中科院分区：
文献类型：
--
作者：
Basu A;Lambring CB
乳腺癌是美国女性癌症相关死亡的第二大原因。Akt信号通路在大约70%的乳腺癌患者中失调。虽然靶向Akt是治疗乳腺癌的有效治疗策略，但Akt家族中有几个成员在乳腺癌中发挥不同的作用。然而，Akt亚型的功能取决于许多因素。本文就Akt亚型在乳腺癌中的功能研究进展作一综述。Akt，也称为蛋白激酶B（PKB），属于蛋白激酶的AGC家族。它作用于磷脂酰肌醇3-激酶（PI 3 K）的下游，调节多种细胞过程，包括细胞增殖、细胞存活、代谢、肿瘤生长和转移。PI 3 K/Akt信号通路在乳腺癌中经常失调，在乳腺癌的发生和发展中起重要作用。Akt家族中有三个密切相关的成员，即Akt 1（PKBα）、Akt 2（PKBβ）和Akt 3（PKBγ）。虽然Akt亚型具有相似的结构，但它们表现出冗余、不同以及相反的功能。虽然Akt信号通路是癌症治疗的重要靶点，但理解Akt的亚型特异性功能对于有效靶向该通路至关重要。然而，随着我们获得新的知识，我们对Akt亚型如何促进乳腺癌发生和发展的看法发生了变化。本文就Akt亚型在乳腺癌中的作用进行综述。
Breast cancer is the second leading cause of cancer-related death in women in the United States. The Akt signaling pathway is deregulated in approximately 70% of patients with breast cancer. While targeting Akt is an effective therapeutic strategy for the treatment of breast cancer, there are several members in the Akt family that play distinct roles in breast cancer. However, the function of Akt isoforms depends on many factors. This review analyzes current progress on the isoform-specific functions of Akt isoforms in breast cancer. Akt, also known as protein kinase B (PKB), belongs to the AGC family of protein kinases. It acts downstream of the phosphatidylinositol 3-kinase (PI3K) and regulates diverse cellular processes, including cell proliferation, cell survival, metabolism, tumor growth and metastasis. The PI3K/Akt signaling pathway is frequently deregulated in breast cancer and plays an important role in the development and progression of breast cancer. There are three closely related members in the Akt family, namely Akt1(PKBα), Akt2(PKBβ) and Akt3(PKBγ). Although Akt isoforms share similar structures, they exhibit redundant, distinct as well as opposite functions. While the Akt signaling pathway is an important target for cancer therapy, an understanding of the isoform-specific function of Akt is critical to effectively target this pathway. However, our perception regarding how Akt isoforms contribute to the genesis and progression of breast cancer changes as we gain new knowledge. The purpose of this review article is to analyze current literatures on distinct functions of Akt isoforms in breast cancer.
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影响因子：
16
作者：
Chen X;Ariss MM;Ramakrishnan G;Nogueira V;Blaha C;Putzbach W;Islam ABMMK;Frolov MV;Hay N
通讯作者：
Hay N
影响因子：
--
作者：
Ávalos Y;Canales J;Bravo-Sagua R;Criollo A;Lavandero S;Quest AF
通讯作者：
Quest AF
影响因子：
8
作者：
Buzzai, M;Bauer, DE;Thompson, CB
通讯作者：
Thompson, CB
影响因子：
7.3
作者：
Baffi TR;Lordén G;Wozniak JM;Feichtner A;Yeung W;Kornev AP;King CC;Del Rio JC;Limaye AJ;Bogomolovas J;Gould CM;Chen J;Kennedy EJ;Kannan N;Gonzalez DJ;Stefan E;Taylor SS;Newton AC
通讯作者：
Newton AC
影响因子：
44.1
作者：
Bae, Seunghee;Kim, Sun-Yong;An, Sungkwan
通讯作者：
An, Sungkwan