Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines.
Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines.
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DOI：
10.1007/s00431-009-0943-y
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发表时间：
2009-12
影响因子：
3.6
通讯作者：
Gehri M
中科院分区：
文献类型：
--
作者：
Cevey-Macherel M;Galetto-Lacour A;Gervaix A;Siegrist CA;Bille J;Bescher-Ninet B;Kaiser L;Krahenbuhl JD;Gehri M
社区获得性肺炎（CAP）是发展中国家的主要死亡原因，也是发达国家的主要发病原因。本研究的目的是确定WHO指南定义的CAP住院儿童的病原体，并将病因与临床严重程度和替代标志物相关联。调查包括广泛的病因学检查。在99例入组患者中，86%检测到潜在病原体，有细菌（53%）、病毒（67%）和混合（33%）感染的证据。肺炎链球菌占CAP的46%。脱水是唯一与细菌性肺炎相关的临床体征。CRP和PCT在细菌感染中显著升高。增加诊断测试的数量可以确定高达86%的儿童CAP的潜在原因，这表明病毒的高流行率和频繁的合并感染。肺炎球菌感染的高比例再次强调了肺炎球菌免疫接种的重要性。
Community-acquired pneumonia (CAP) is a major cause of death in developing countries and of morbidity in developed countries. The objective of the study was to define the causative agents among children hospitalized for CAP defined by WHO guidelines and to correlate etiology with clinical severity and surrogate markers. Investigations included an extensive etiological workup. A potential causative agent was detected in 86% of the 99 enrolled patients, with evidence of bacterial (53%), viral (67%), and mixed (33%) infections. Streptococcus pneumoniae was accounted for in 46% of CAP. Dehydration was the only clinical sign associated with bacterial pneumonia. CRP and PCT were significantly higher in bacterial infections. Increasing the number of diagnostic tests identifies potential causes of CAP in up to 86% of children, indicating a high prevalence of viruses and frequent co-infections. The high proportion of pneumococcal infections re-emphasizes the importance of pneumococcal immunization.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1164/rccm.200406-781oc
发表时间：
2004-12-01
影响因子：
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作者：
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通讯作者：
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