Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts--from the point of view of mouse genomics.
Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts--from the point of view of mouse genomics.
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DOI：
10.1016/j.intimp.2012.02.014
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发表时间：
2012-05
影响因子：
5.6
通讯作者：
Gu W
中科院分区：
文献类型：
--
作者：
Cao Y;Jiao Y;Wang L;Huang Y;Postlethwaite A;Stuart J;Kang A;Williams RW;Gu W
IL-1受体拮抗剂（IL-1 rn）是与IL-1受体（IL-1 r1）结合并抑制IL-1α和IL-1β结合的蛋白质。近年来，IL-1 rn被认为与许多人类健康问题有关。阿那白滞素（一种白介素-1（IL-1）受体拮抗剂）治疗几种炎症性疾病的效果也有报道。积极和消极的影响都有描述。在这篇综述中，我们系统地分析了IL-1 rn和它的13个伙伴基因的表达，相关性和调节使用现有的基因表达谱从各种组织中的一个众所周知的转录组数据库，Genenetwork。这13个伴侣基因包括IL-1 r1、IL-1β、IL-1α、Myd 88、Myk 1、Myk 2、Myk 4、Traf 6、Tlr 4、IL-1 rap、Ikbkap、Nfkb 1和Nfkb 2。基因表达谱来自10个组织，包括脾、肾、肺、全脑、眼、前额叶皮质、小脑、海马、纹状体和丘脑核。我们的分析表明，IL-1 rn和它的合作伙伴之间的相互作用是复杂的，不同的组织，表明IL-1 rn的生物学和代谢途径的影响是广谱的。IL-1 rn的转录本和蛋白质序列的不同剪接、与个体基因组背景的相互作用以及环境因素影响其功能。目前，我们对IL-1 rn及其配偶体在各种组织或器官中的功能的了解非常有限。阿那白滞素对人体健康的长期和长期影响需要进一步研究。在未来，IL-1 rn的靶向序列或寡核苷酸可能是理想的治疗应用，具有更低的毒性和更特异性的治疗特定疾病。深入研究IL-1 rn的分子功能及其与其他基因和环境因素的相互作用对开发IL-1 rn的治疗应用至关重要。
IL-1 receptor antagonist (IL-1rn) is a protein that binds to IL-1 receptors (IL-1r1) and inhibits the binding of IL-1α and IL-1β. In recent years, IL-1rn has been implicated to be associated with many human health problems. The effects of treatment of several inflammatory disorders with anakinra, which is an interleukin-1 (IL-1) receptor antagonist, have also been reported. Both positive and negative effects have been described. In this review, we systematically analyzed the expression, correlation, and regulation of IL-1rn and its 13 partner genes using available gene expression profiles from a variety of tissues in a well known transcriptome database, Genenetwork. The 13 partner genes include IL-1r1, IL-1β, IL-1α, Myd88, Irak1, Irak2, Irak4, Traf6, Tlr4, IL-1rap, Ikbkap, Nfkb1, and Nfkb2. Gene expression profiles are from 10 tissues including spleen, kidney, lung, whole brain, eye, prefrontal cortex, cerebellum, hippocampus, striatum, and nucleus accumbens. Our analysis indicated that the interactions among IL-1rn and its partner are complex and different from tissues to tissues, suggesting a broad spectrum of the effect of IL-1rn on biological and metabolic pathways. Transcripts and protein sequences resulted from different splicing, interaction with genomic background of individuals, and environmental factors affect function of IL-1rn. At present, our knowledge on the function of IL-1rn and its partner in various tissues or organs is very limited. The long term and extended effect of anakinra on human health needs further investigations. In the future, targeted sequences or oligos of Il-1rn might be ideal for therapeutic application with less toxic and more specific in the treatment of specific disease. Detailed study on the molecular function of IL-1rn and its interaction with other genes and environmental factors is essential for development therapeutic application using IL-1rn.
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DOI：
10.1084/jem.191.2.313
发表时间：
2000-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Horai R;Saijo S;Tanioka H;Nakae S;Sudo K;Okahara A;Ikuse T;Asano M;Iwakura Y
通讯作者：
Iwakura Y
影响因子：
27.4
作者：
Bodar, E. J.;Kuijk, L. M.;Frenkel, J.
通讯作者：
Frenkel, J.
影响因子：
--
作者：
Nigrovic, Peter A.;Mannion, Melissa;Higgins, Gloria C.
通讯作者：
Higgins, Gloria C.
DOI：
10.1056/nejmoa0807865
发表时间：
2009-06-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Aksentijevich I;Masters SL;Ferguson PJ;Dancey P;Frenkel J;van Royen-Kerkhoff A;Laxer R;Tedgård U;Cowen EW;Pham TH;Booty M;Estes JD;Sandler NG;Plass N;Stone DL;Turner ML;Hill S;Butman JA;Schneider R;Babyn P;El-Shanti HI;Pope E;Barron K;Bing X;Laurence A;Lee CC;Chapelle D;Clarke GI;Ohson K;Nicholson M;Gadina M;Yang B;Korman BD;Gregersen PK;van Hagen PM;Hak AE;Huizing M;Rahman P;Douek DC;Remmers EF;Kastner DL;Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R
影响因子：
2.6
作者：
Arman, Ahmet;Soylu, Ozer;Tezel, Tuna
通讯作者：
Tezel, Tuna