Insertion mechanics of amorphous SiC ultra-micro scale neural probes.
Insertion mechanics of amorphous SiC ultra-micro scale neural probes.
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DOI：
10.1088/1741-2552/ac5bf4
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发表时间：
2022-04-08
影响因子：
4
通讯作者：
Varner, Victor D.
中科院分区：
文献类型：
--
作者：
Geramifard, Negar;Dousti, Behnoush;Nguyen, Christopher;Abbott, Justin;Cogan, Stuart F.;Varner, Victor D.
由微电极插入皮层神经组织引起的创伤是一个重要的问题。此外，微电极探针和神经组织之间的微动和机械失配与不良异物反应（FBR）有关。因此，皮质内超微电极探针已被提议作为替代方案，以最大限度地减少这种FBR。然而，在植入这些柔性探针方面仍然存在重大挑战。我们研究了无定形碳化硅（a-SiC）探头的插入力学，以确定可以插入皮质而不会弯曲的探头几何形状。我们确定的临界屈曲力的a-SiC探针作为探针的几何形状的函数，然后通过测量插入到琼脂糖凝胶和大鼠皮层过程中的力-位移响应，这些探针的屈曲行为的特征。确定一系列探针几何形状的插入力，并与临界屈曲力进行比较，以确定植入大脑期间应避免屈曲的几何形状。研究表明，较慢的插入速度会降低单柄探针的最大插入力，但会增加多柄探针插入过程中的皮质凹陷。我们的研究结果提供了一个指南，选择探针的几何形状和插入速度，允许独立植入到大鼠大脑皮层的探针。该设计方法适用于需要将皮质内探针插入2 mm深度的其他动物模型。
Trauma induced by the insertion of microelectrodes into cortical neural tissue is a significant problem. Further, micromotion and mechanical mismatch between microelectrode probes and neural tissue is implicated in an adverse foreign body response (FBR). Hence, intracortical ultra-microelectrode probes have been proposed as alternatives that minimize this FBR. However, significant challenges in implanting these flexible probes remain. We investigated the insertion mechanics of amorphous silicon carbide (a-SiC) probes with a view to defining probe geometries that can be inserted into cortex without buckling. We determined the critical buckling force of a-SiC probes as a function of probe geometry and then characterized the buckling behavior of these probes by measuring force-displacement responses during insertion into agarose gel and rat cortex. Insertion forces for a range of probe geometries were determined and compared with critical buckling forces to establish geometries that should avoid buckling during implantation into brain. The studies show that slower insertion speeds reduce the maximum insertion force for single-shank probes but increase cortical dimpling during insertion of multi-shank probes. Our results provide a guide for selecting probe geometries and insertion speeds that allow unaided implantation of probes into rat cortex. The design approach is applicable to other animal models where insertion of intracortical probes to a depth of 2 mm is required.
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