Role of bone architecture and anatomy in osteoarthritis.
Role of bone architecture and anatomy in osteoarthritis.
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骨结构和解剖学在骨关节炎中的作用。
DOI：
10.1016/j.bone.2012.01.008
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发表时间：
2012-08
期刊：
影响因子：
4.1
通讯作者：
Lane, Nancy E.
中科院分区：
文献类型：
--
作者：
Baker-LePain, Julie C.;Lane, Nancy E.
当考虑骨关节炎（OA）的发病机制时，除了软骨和滑膜的贡献外，审查骨的贡献是重要的。虽然骨在确定关节间生物力学力的分布中明显起作用，而关节间生物力学力的分布又在OA的发生中起作用，但最近人们还认识到，骨可能在生物学意义上有助于OA的发病机制。骨远不是静态结构，而是经历不断重塑的动态组织，并且从许多放射学和生物化学研究中可以清楚地看出，骨和软骨降解同时发生。OA的初始诱发事件是否发生在软骨或骨中尚不清楚，但很明显，骨变化发生在OA发病机制的早期，通常早于疾病的影像学表现。本文综述了与OA相关的髋关节和膝关节的结构变异，以及这些部位在早期OA发病机制中发生的超微结构骨变化。
When considering the pathogenesis of osteoarthritis (OA), it is important to review the contribution of bone in addition to the contribution of cartilage and synovium. Although bone clearly plays a role in determining the distribution of biomechanical forces across joints, which in turn plays a role in the initiation of OA, it has also more recently been appreciated that bone may contribute in a biological sense to the pathogenesis of OA. Far from being a static structure, bone is a dynamic tissue undergoing constant remodeling, and it is clear from a number of radiographic and biochemical studies that bone and cartilage degradation occur hand in hand. Whether the initial instigating event in OA occurs in cartilage or bone is not known, but it is clear that bony changes occur very early in the pathogenesis of OA and often predate radiographic appearance of the disease. This review focuses on the structural variants of both hip and knee that have been associated with OA and the ultrastructural bone changes in these sites occurring in early OA pathogenesis.
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影响因子：
2.4
作者：
Bredbenner, Todd L.;Eliason, Travis D.;Potter, Ryan S.;Mason, Robert L.;Havill, Lorena M.;Nicolella, Daniel P.
通讯作者：
Nicolella, Daniel P.
影响因子：
--
作者：
Evangelou, Evangelos;Chapman, Kay;Meulenbelt, Ingrid;Karassa, Fotini B.;Loughlin, John;Carr, Andrew;Doherty, Michael;Doherty, Sally;Gomez-Reino, Juan J.;Gonzalez, Antonio;Halldorsson, Bjarni V.;Hauksson, Valdimar B.;Hofman, Albert;Hart, Deborah J.;Ikegawa, Shiro;Ingvarsson, Thorvaldur;Jiang, Qing;Jonsdottir, Ingileif;Jonsson, Helgi;Kerkhof, Hanneke J. M.;Kloppenburg, Margreet;Lane, Nancy E.;Li, Jia;Lories, Rik J.;van Meurs, Joyce B. J.;Nakki, Annu;Nevitt, Michael C.;Rodriguez-Lopez, Julio;Shi, Dongquan;Slagboom, Eline;Stefansson, Kari;Tsezou, Aspasia;Wallis, Gillian A.;Watson, Christopher M.;Spector, Tim D.;Uitterlinden, Andre G.;Valdes, Ana M.;Ioannidis, John P. A.
通讯作者：
Ioannidis, John P. A.
影响因子：
27.4
作者：
Arokoski, JPA;Arokoski, MH;Kröger, H
通讯作者：
Kröger, H
影响因子：
--
作者：
Blair-Levy, J. M.;Watts, C. E.;Lipsky, P. E.
通讯作者：
Lipsky, P. E.
DOI：
10.1097/01.blo.0000096804.78689.c2
发表时间：
2003-12-01
影响因子：
4.2
作者：
Ganz, R;Parvizi, J;Siebenrock, KA
通讯作者：
Siebenrock, KA