The role of endothelial-to-mesenchymal transition in cancer progression.
The role of endothelial-to-mesenchymal transition in cancer progression.
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DOI：
10.1038/sj.bjc.6604662
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发表时间：
2008-11-04
影响因子：
8.8
通讯作者：
Kalluri R
中科院分区：
文献类型：
--
作者：
Potenta S;Zeisberg E;Kalluri R
最近的证据表明，内皮-间充质转化(EndMT)可能在许多疾病中发挥重要作用。虽然EndMT以前被认为是心脏发育的关键过程，但现在清楚的是，EndMT也可以在出生后的各种病理环境中发生，包括癌症和心脏纤维化。在EndMT过程中，常驻内皮细胞从有组织的细胞层剥离，获得间充质表型，其特征是细胞-细胞连接丢失，内皮标志物丢失，间充质标志物获得，以及获得侵袭和迁移特性。内皮-间充质转化衍生细胞被认为在受损组织中作为成纤维细胞发挥作用，因此可能在组织重建和纤维化中发挥重要作用。在肿瘤中，EndMT是癌症相关成纤维细胞(CAF)的重要来源，已知CAF以多种方式促进肿瘤进展。这些新发现表明，靶向EndMT可能是一种新的治疗策略，不仅广泛适用于癌症，而且还适用于各种其他疾病状态。
Recent evidence has demonstrated that endothelial-to-mesenchymal transition (EndMT) may have a significant role in a number of diseases. Although EndMT has been previously studied as a critical process in heart development, it is now clear that EndMT can also occur postnatally in various pathologic settings, including cancer and cardiac fibrosis. During EndMT, resident endothelial cells delaminate from an organised cell layer and acquire a mesenchymal phenotype characterised by loss of cell–cell junctions, loss of endothelial markers, gain of mesenchymal markers, and acquisition of invasive and migratory properties. Endothelial-to-mesenchymal transition -derived cells are believed to function as fibroblasts in damaged tissue, and may therefore have an important role in tissue remodelling and fibrosis. In tumours, EndMT is an important source of cancer-associated fibroblasts (CAFs), which are known to facilitate tumour progression in several ways. These new findings suggest that targeting EndMT may be a novel therapeutic strategy, which is broadly applicable not only to cancer but also to various other disease states.
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影响因子：
--
作者：
MARKWALD, RR;FITZHARRIS, TP;MANASEK, FJ
通讯作者：
MANASEK, FJ
DOI：
10.1073/pnas.1434429100
发表时间：
2003-09-16
影响因子：
11.1
作者：
Chi, JT;Chang, HY;Brown, PO
通讯作者：
Brown, PO
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
10.5
作者：
Timmerman, LA;Grego-Bessa, J;de la Pompa, JL
通讯作者：
de la Pompa, JL
影响因子：
20.1
作者：
Frid, MG;Kale, VA;Stenmark, KR
通讯作者：
Stenmark, KR