The unity of opposites: Strategic interplay between bacterial effectors to regulate cellular homeostasis.
The unity of opposites: Strategic interplay between bacterial effectors to regulate cellular homeostasis.
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DOI：
10.1016/j.jbc.2021.101340
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Das C
中科院分区：
文献类型：
--
作者：
Iyer S;Das C
嗜肺军团菌是一种兼性胞内病原体，它利用Dot/Icm Ⅳ型分泌系统（T4SS）将众多效应蛋白转运至宿主细胞内，从而营造一个安全的、利于自身繁殖的生存环境。该细菌一旦被吞噬，就会寄居于宿主细胞内一种称为含军团菌液泡（LCV）的液泡结构中，并迅速破坏细胞器运输过程、阻断炎症反应、劫持宿主的泛素化系统以及消除凋亡信号。这些转运的效应蛋白能够以多种不同方式操控宿主因子。这些蛋白还通过正向或负向调节彼此的活性来增强细菌的毒力。这种直接或间接的效应蛋白 - 效应蛋白相互作用，为在宿主体内生存的同时维持细胞内稳态提供了所需的微妙平衡。本综述总结了我们在了解军团菌中部分相互拮抗的效应蛋白对的结构 - 功能关系及生化机制方面的最新进展，同时突出了这种胞内病原体为在宿主细胞内建立繁殖生态位所采用的生化手段的多样性。
Legionella pneumophila is a facultative intracellular pathogen that uses the Dot/Icm Type IV secretion system (T4SS) to translocate many effectors into its host and establish a safe, replicative lifestyle. The bacteria, once phagocytosed, reside in a vacuolar structure known as the Legionella-containing vacuole (LCV) within the host cells and rapidly subvert organelle trafficking events, block inflammatory responses, hijack the host ubiquitination system, and abolish apoptotic signaling. This arsenal of translocated effectors can manipulate the host factors in a multitude of different ways. These proteins also contribute to bacterial virulence by positively or negatively regulating the activity of one another. Such effector–effector interactions, direct and indirect, provide the delicate balance required to maintain cellular homeostasis while establishing itself within the host. This review summarizes the recent progress in our knowledge of the structure–function relationship and biochemical mechanisms of select effector pairs from Legionella that work in opposition to one another, while highlighting the diversity of biochemical means adopted by this intracellular pathogen to establish a replicative niche within host cells.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
Science (New York, N.Y.)
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