Use of convalescent plasma therapy in SARS patients in Hong Kong.

Use of convalescent plasma therapy in SARS patients in Hong Kong.
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DOI:
10.1007/s10096-004-1271-9
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发表时间:
2005-01
期刊:
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子:
--
通讯作者:
Cheng G
Cheng G
中科院分区:
其他
文献类型:
--
作者:
Cheng Y;Wong R;Soo YO;Wong WS;Lee CK;Ng MH;Chan P;Wong KC;Leung CB;Cheng G

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为了评估恢复期血浆疗法对严重急性呼吸系统综合症(SARS)患者的治疗效果,2003年3月20日至5月26日期间,80名SARS患者在香港威尔斯亲王医院接受了恢复期血浆治疗。良好结果的定义是在SARS症状出现后第22天出院。不良结果定义为死亡或住院超过 22 天。在发病第 14 天前接受恢复期血浆的患者(58.3% vs 15.6%;P<0.001)以及输注血浆时 PCR 阳性且冠状病毒血清阴性的患者中,第 22 天出院率较高(66.7% vs 20%;P=0.001)。
In order to evaluate the efficacy of convalescent plasma therapy in the treatment of patients with severe acute respiratory syndrome (SARS), 80 SARS patients were given convalescent plasma at Prince of Wales Hospital, Hong Kong, between 20 March and 26 May 2003. Good outcome was defined as discharge by day 22 following the onset of SARS symptoms. Poor outcome was defined as death or hospitalization beyond 22 days. A higher day-22 discharge rate was observed among patients who were given convalescent plasma before day 14 of illness (58.3% vs 15.6%; P<0.001) and among those who were PCR positive and seronegative for coronavirus at the time of plasma infusion (66.7% vs 20%; P=0.001).
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影响因子: --
作者:
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