The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study.
The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study.
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DOI：
10.1111/jdi.12633
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发表时间：
2017-09
影响因子：
3.2
通讯作者：
Inoue S
中科院分区：
文献类型：
--
作者：
Nitta H;Katagiri S;Nagasawa T;Izumi Y;Ishikawa I;Izumiyama H;Uchimura I;Kanazawa M;Chiba H;Matsuo A;Utsunomiya K;Tanabe H;Takei I;Asanami S;Kajio H;Ono T;Hayashi Y;Ueki K;Tsuji M;Kurachi Y;Yamanouchi T;Ichinokawa Y;Inokuchi T;Fukui A;Miyazaki S;Miyauchi T;Kawahara R;Ogiuchi H;Yoshioka N;Negishi J;Mori M;Mogi K;Saito Y;Tanzawa H;Nishikawa T;Takada N;Nanjo K;Morita N;Nakamura N;Kanamura N;Makino H;Nishimura F;Kobayashi K;Higuchi Y;Sakata T;Yanagisawa S;Tei C;Ando Y;Hanada N;Inoue S
目的探讨2型糖尿病患者牙周炎与微血管并发症及血糖控制的关系。这项多中心、以医院为基础的横断面研究纳入了620例2型糖尿病患者。我们比较了有微血管并发症和无微血管并发症患者牙周炎的患病率和严重程度。我们还比较了不同血糖控制程度患者牙周炎的患病率和严重程度。校正混杂因素后，多元logistic回归分析显示，牙周炎严重程度与微血管并发症数量（优势比1.3,95%可信区间1.1 ~ 1.6）、糖化血红蛋白≥8.0% （64 mmol/mol，优势比1.6,95%可信区间1.1 ~ 2.3）、年龄（≥50岁，优势比1.7,95%可信区间1.1 ~ 2.6）显著相关。然而，牙周炎的患病率与微血管并发症数量无显著相关性，但与男性、高糖化血红蛋白（≥8.0% [64 mmol/mol]）、年龄较大（≥40岁）、糖尿病病程较长（≥15年）和牙齿较少（≤25颗）相关。此外，年龄、性别、糖尿病病程、糖化血红蛋白的倾向评分匹配显示，有微血管并发症的患者严重牙周炎的发生率明显高于无微血管并发症的患者（P < 0.05）。微血管并发症的数量是2型糖尿病患者更严重牙周炎的一个危险因素，而血糖控制不良是牙周炎患病率和严重程度增加的一个危险因素。
To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. This multicenter, hospital‐based, cross‐sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.
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影响因子：
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通讯作者：
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