Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear.
Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear.
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DOI：
10.1007/s00429-016-1205-1
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发表时间：
2017-01
影响因子：
3.1
通讯作者：
Hidalgo-Sánchez M
中科院分区：
文献类型：
--
作者：
Olaya-Sánchez D;Sánchez-Guardado LÓ;Ohta S;Chapman SC;Schoenwolf GC;Puelles L;Hidalgo-Sánchez M
内耳是具有听觉和前庭功能的复杂感觉结构。发育中的耳上皮产生成人膜迷路的神经感觉和非感觉元件。外源性和内源性信号通过建立由调节基因的差异表达定义的谱系限制性隔室来管理发育中的耳上皮的图案化和细胞规格。FGF3和FGF16是控制这些发育事件的优秀候选者。在鸡，我们发现，Fgf3的表达存在于所有发展中的嵴的边界。强Fgf16的表达被检测到的一部分发展中的垂直和水平的邮袋，而嵴表现出较弱或未检测到Fgf16的表达在不同的发展阶段。至于其余的前庭感觉元件，椭圆囊和囊状斑Fgf 3阳性。有趣的是，强烈的Fgf16表达界定了这些Fgf16阴性感觉斑。Fgf16弱表达区域包括Fgf3阴性的忽略斑和Fgf3阳性的兔眼斑。因此，不同的FGF介导的机制可能会调节前（椭圆囊和囊状）和后（忽略和lagena）黄斑的规格。在发育中的耳蜗导管中，动态的Fgf3和Fgf16表达表明它们在听觉系统的早期特化和后期细胞分化中的合作。本文还讨论了Fgf3和Fgf16基因在内淋巴器发育和神经发生中的必要性。基于这些观察，FGF 3和FGF 16似乎是通过限定发育中的耳上皮内的上皮身份来控制内耳计划的关键信号传导途径。
The inner ear is a complex sensorial structure with auditory and vestibular functions. The developing otic epithelium gives rise to neurosensory and non-sensory elements of the adult membranous labyrinth. Extrinsic and intrinsic signals manage the patterning and cell specification of the developing otic epithelium by the establishment of lineage-restricted compartments defined in turn by differential expressions of regulatory genes. FGF3 and FGF16 are excellent candidates to govern these developmental events. In the chick, we showed that Fgf3 expression was present in the borders of all developing cristae. Strong Fgf16 expressions were detected in a portion of the developing vertical and horizontal pouches, whereas the cristae showed weaker or undetected Fgf16 expressions at different developmental stages. Concerning the rest of the vestibular sensory elements, both the utricular and saccular maculae were Fgf3 positive. Interestingly, a strong Fgf16 expression delimited these Fgf16-negative sensory patches. The Fgf3-negative macula neglecta and Fgf3-positive macula lagena were included within weakly Fgf16-expressing areas. Therefore, different FGF-mediated mechanisms might regulate the specification of the anterior (utricular and saccular) and posterior (neglecta and lagena) maculae. In the developing cochlear duct, the dynamic Fgf3 and Fgf16 expressions suggest their co-operation in the early specification and later cell differentiation in the hearing system. The requirement of Fgf3 and Fgf16 genes in endolymphatic apparatus development and neurogenesis are discussed. Based on these observations, FGF3 and FGF16 appear to be key signaling pathways to control the inner ear plan by means of defining epithelial identities within the developing otic epithelium.
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影响因子：
4.6
作者：
Alvarez, Y;Alonso, MT;Schimmang, T
通讯作者：
Schimmang, T
影响因子：
2.7
作者：
Alsina, B;Abelló, G;Giraldez, F
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5.2
作者：
Alsmadi, Osama;Meyer, Brian F.;Al-Sayed, MoeenAldeen
通讯作者：
Al-Sayed, MoeenAldeen
影响因子：
2.5
作者：
Chapman, Susan C.;Cai, Qin;Schoenwolf, Gary C.
通讯作者：
Schoenwolf, Gary C.
影响因子：
3.5
作者：
Gregory-Evans, Cheryl Y.;Moosajee, Mariya;Gregory-Evans, Kevin
通讯作者：
Gregory-Evans, Kevin