Genetic differences in the effect of ethanol on plasma corticosterone and nonesterified fatty acid in rats.
Genetic differences in the effect of ethanol on plasma corticosterone and nonesterified fatty acid in rats.
复制标题
乙醇对大鼠血浆皮质酮和非酯化脂肪酸影响的遗传差异。
DOI：
10.1111/j.1530-0277.1984.tb05712.x
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
L. Pohorecky
中科院分区：
文献类型：
--
作者：
L. Pohorecky
基因型对啮齿动物乙醇反应性的影响进行了研究，使用生化措施。9种不同品系的大鼠用生理盐水或不同剂量的乙醇处理，1小时后测量血浆皮质酮和非酯化游离脂肪酸的变化。结果发现，BUF/N品系大鼠对两种测量的反应最低，血液乙醇水平也最低。对乙醇最敏感的菌株是ACI/N相对于皮质酮，WKY/N和M520/N相对于非酯化游离脂肪酸。在MR/N和WKY/N品系大鼠中观察到最高的血液乙醇水平。
The influence of genotype on the responsiveness to ethanol in rodents was examined using biochemical measures. Nine different strains of rats were treated with saline or various doses of ethanol, and the changes in plasma corticosterone and of nonesterified free fatty acids were measured 1 hr later. It was found that the BUF/N strain of rats had the lowest response on both measures and also had the lowest blood ethanol levels. The most sensitive strains to ethanol were the ACI/N with respect to corticosterone, and WKY/N and M520/N with respect to nonesterified free fatty acids. The highest blood ethanol levels were seen in the MR/N and the WKY/N strains of rats.
DOI：
10.1111/j.1530-0277.1984.tb05707.x
发表时间：
1984
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
Spuhler,K;Deitrich,RA
通讯作者：
Deitrich,RA