The genetic architecture underlying prey-dependent performance in a microbial predator.
The genetic architecture underlying prey-dependent performance in a microbial predator.
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微生物捕食者依赖猎物表现的遗传结构。
DOI：
10.1038/s41467-021-27844-x
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发表时间：
2022-01-14
影响因子：
16.6
通讯作者：
Thompson CRL
中科院分区：
文献类型：
--
作者：
Stewart B;Gruenheit N;Baldwin A;Chisholm R;Rozen D;Harwood A;Wolf JB;Thompson CRL
自然选择应该倾向于通才捕食者，它们在所有猎物类型中都比专才捕食者表现得更好。两种遗传解决方案可以解释为什么捕食行为的种内变异如此普遍：对一种猎物有利的突变对另一种猎物来说代价高昂（拮抗多效性），或者突变效应是猎物特异性的，这削弱了选择，允许变异持续存在（松弛选择）。为了了解这些选择的相对重要性，我们描述了微生物捕食者盘齿龙捕食性能的自然变化。我们发现菌株在不同细菌猎物间的捕食成功率存在广泛的非传递性差异，这有助于菌株在多猎物环境中共存。为了了解遗传基础，我们开发了不同猎物的高通量实验进化方法（REMI-seq）。大多数突变（约77%）具有猎物特异性作用，极少数突变（约4%）表现为拮抗多效性。这突出了猎物特异性效应淡化选择的可能性，这将抑制变异的清除，并防止出现最佳的通才捕食者。是什么阻碍了通才捕食者进化并超越专才捕食者？通过结合自然变异和实验进化的分析，Stewart等人认为，捕食者变异之所以持续存在，是因为大多数突变具有特定于猎物的效应，这导致了宽松的选择
Natural selection should favour generalist predators that outperform specialists across all prey types. Two genetic solutions could explain why intraspecific variation in predatory performance is, nonetheless, widespread: mutations beneficial on one prey type are costly on another (antagonistic pleiotropy), or mutational effects are prey-specific, which weakens selection, allowing variation to persist (relaxed selection). To understand the relative importance of these alternatives, we characterised natural variation in predatory performance in the microbial predator Dictyostelium discoideum. We found widespread nontransitive differences among strains in predatory success across different bacterial prey, which can facilitate stain coexistence in multi-prey environments. To understand the genetic basis, we developed methods for high throughput experimental evolution on different prey (REMI-seq). Most mutations (~77%) had prey-specific effects, with very few (~4%) showing antagonistic pleiotropy. This highlights the potential for prey-specific effects to dilute selection, which would inhibit the purging of variation and prevent the emergence of an optimal generalist predator. What prevents a generalist predator from evolving and outperforming specialist predators? By combing analyses of natural variation with experimental evolution, Stewart et al. suggest that predator variation persists because most mutations have prey-specific effects, which results in relaxed selection
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影响因子：
16.8
作者：
Des Roches, Simone;Post, David M.;Palkovacs, Eric P.
通讯作者：
Palkovacs, Eric P.
影响因子：
11.4
作者：
Anderson, Jill T.;Willis, John H.;Mitchell-Olds, Thomas
通讯作者：
Mitchell-Olds, Thomas
影响因子：
2.9
作者：
Cruickshank, Tami;Wade, Michael J.
通讯作者：
Wade, Michael J.
影响因子：
4.9
作者：
Gardner, KM;Latta, RG
通讯作者：
Latta, RG
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y