Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity.
Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity.
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DOI：
10.1016/j.cyto.2008.07.004
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发表时间：
2008-10
期刊：
影响因子：
3.8
通讯作者：
Bartfai, T.
中科院分区：
文献类型：
--
作者：
Osborn, O.;Brownell, S. E.;Sanchez-Alavez, M.;Salomon, D.;Gram, H.;Bartfai, T.
促炎细胞因子白细胞介素1 β（IL-1β）在肥胖个体和啮齿类动物中升高，并与胰岛素分泌受损、细胞增殖减少和胰腺β细胞凋亡有关。在这项研究中，我们描述了IL-1β抗体对改善饮食诱导肥胖的高血糖小鼠的血糖控制的治疗作用。治疗13周后，IL-1β抗体治疗组显示相对于对照抗体治疗组降低的糖化血红蛋白（*P = 0.049）、降低的血清胰岛素原水平（*P = 0.015）、降低的胰岛素水平和较小的胰岛大小（*P = 1.65 E-13）。IL-1β的中和也显著降低血清淀粉样蛋白A（SAA），这是炎症诱导的急性期反应的指标（*P = 0.024）。虽然肥胖没有改善，但通过这种药理学治疗实现了血糖控制和β细胞功能的显著改善，这可以减缓/预防2型糖尿病的疾病进展。
The proinflammatory cytokine Interleukin 1 beta (IL-1β) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. In this study we describe the therapeutic effects by an IL-1β antibody to improve glucose control in hyperglycemic mice with diet induced obesity. After 13wks of treatment the IL-1β antibody treated group showed reduced glycated hemoglobin (*P = 0.049), reduced serum levels of proinsulin (*P = 0.015), reduced levels of insulin and smaller islet size (*P = 1.65E-13) relative to the control antibody treated group. Neutralization of IL-1β also significantly reduced serum amyloid A (SAA) which is an indicator of inflammation-induced acute phase response (*P = 0.024). While there was no improvement of obesity, a significant improvement of glycemic control and of beta cell function is achieved by this pharmacological treatment which may slow/prevent disease progression in Type 2 Diabetes.
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