Blockchain technology for improving clinical research quality.
Blockchain technology for improving clinical research quality.
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DOI：
10.1186/s13063-017-2035-z
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发表时间：
2017-07-19
期刊：
影响因子：
2.5
通讯作者：
Ravaud P
中科院分区：
文献类型：
--
作者：
Benchoufi M;Ravaud P
重现性，数据共享，个人数据隐私问题和临床试验中的患者增强是当代临床研究的巨大医疗挑战，这是一种新技术，可能是应对这些挑战的关键，应该引起整个临床研究社区的关注。
区块链将互联网带到了确定的权力下放目标。信任，但通过复杂的加密算法在区块链协议中进行了硬编码。区块链允许在临床试验中达到整个文件流的历史和不可侵犯，因此可以确保可食用性，可防止后验重建，并通过所谓的智能合同安全地自动化临床试验同时，该技术可确保单个患者或一组患者或临床试验的数据，其安全性和可共享参数的细粒度控制利益相关者。
在这篇评论文章中，我们探讨了应用于临床试验的区块链的核心功能，并在同意方案中阐明了其一般原则，试图找出区块链实施在临床试验中的潜在影响。关于现代临床试验方法如何从区块链技术中发展和受益，以应对PRIORE挑战，从而有了新的启示。
Reproducibility, data sharing, personal data privacy concerns and patient enrolment in clinical trials are huge medical challenges for contemporary clinical research. A new technology, Blockchain, may be a key to addressing these challenges and should draw the attention of the whole clinical research community. Blockchain brings the Internet to its definitive decentralisation goal. The core principle of Blockchain is that any service relying on trusted third parties can be built in a transparent, decentralised, secure “trustless” manner at the top of the Blockchain (in fact, there is trust, but it is hardcoded in the Blockchain protocol via a complex cryptographic algorithm). Therefore, users have a high degree of control over and autonomy and trust of the data and its integrity. Blockchain allows for reaching a substantial level of historicity and inviolability of data for the whole document flow in a clinical trial. Hence, it ensures traceability, prevents a posteriori reconstruction and allows for securely automating the clinical trial through what are called Smart Contracts. At the same time, the technology ensures fine-grained control of the data, its security and its shareable parameters, for a single patient or group of patients or clinical trial stakeholders. In this commentary article, we explore the core functionalities of Blockchain applied to clinical trials and we illustrate concretely its general principle in the context of consent to a trial protocol. Trying to figure out the potential impact of Blockchain implementations in the setting of clinical trials will shed new light on how modern clinical trial methods could evolve and benefit from Blockchain technologies in order to tackle the aforementioned challenges.
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影响因子：
15.8
作者：
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通讯作者：
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