Ionizing radiation increases systemic nanoparticle tumor accumulation.
Ionizing radiation increases systemic nanoparticle tumor accumulation.
复制标题
DOI：
10.1016/j.nano.2012.05.001
复制
发表时间：
2012-08
影响因子：
5.4
通讯作者：
Hoopes, P. Jack
中科院分区：
文献类型：
--
作者：
Giustini, Andrew J.;Petryk, Alicia A.;Hoopes, P. Jack
目前，人们正在探索基于纳米颗粒的治疗方法，用于原发和转移癌症的成像和治疗。有效的纳米粒子癌症治疗需要在肿瘤环境中大量积累纳米粒子。各种技术已经被用来改善肿瘤纳米颗粒的摄取和生物分布。这些技术中最值得注意的是使用肿瘤特异性多肽偶联纳米颗粒和用免疫逃避聚合物对纳米颗粒进行化学修饰。另一种改善肿瘤对纳米粒摄取的策略是改变肿瘤微环境，目的是增强实体肿瘤固有的渗透性和保留性。在同基因小鼠乳腺肿瘤模型中，我们证明了在单次15Gy射线照射后，系统输送的氧化铁纳米颗粒的肿瘤蓄积量增加了两倍。这种纳米颗粒肿瘤积聚的增加与辐射引起的肿瘤间质压力的降低和随后血管通透性的增加有关。
Nanoparticle-based therapies are currently being explored for both the imaging and treatment of primary and metastatic cancers. Effective nanoparticle cancer therapy requires significant accumulations of nanoparticles within the tumor environment. Various techniques have been used to improve tumor nanoparticle uptake and biodistribution. Most notable of these techniques are the use of tumor-specific-peptide-conjugated nanoparticles and chemical modification of the nanoparticles with immune-evading polymers. Another strategy for improving the tumor uptake of the nanoparticles is modification of the tumor microenvironment with a goal of enhancing the enhanced permeability and retention effect inherent to solid tumors. We demonstrate a two-fold increase in the tumor accumulation of systemically delivered iron oxide nanoparticles following a single, 15 Gy radiation dose in a syngeneic mouse breast tumor model. This increase in nanoparticle tumor accumulation correlates with a radiation-induced decrease in tumor interstitial pressure and a subsequent increase in vascular permeability.
登录
查看更多内容
影响因子：
11.5
作者：
Chen, B;Pogue, BW;Hasan, T
通讯作者：
Hasan, T
影响因子：
78.8
作者：
Jain, Rakesh K.;Stylianopoulos, Triantafyllos
通讯作者：
Stylianopoulos, Triantafyllos
影响因子：
3.1
作者：
Ozerdem, U;Hargens, AR
通讯作者：
Hargens, AR
影响因子：
4.5
作者：
Greish, Khaled
通讯作者：
Greish, Khaled
影响因子：
0.8
作者：
Giustini AJ;Petryk AA;Cassim SM;Tate JA;Baker I;Hoopes PJ
通讯作者：
Hoopes PJ