Transmission of Mycobacterium tuberculosis Beijing Strains, Alberta, Canada, 1991-2007.
Transmission of Mycobacterium tuberculosis Beijing Strains, Alberta, Canada, 1991-2007.
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DOI：
10.3201/eid1905.121578
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发表时间：
2013-05
影响因子：
11.8
通讯作者：
Long R
中科院分区：
文献类型：
--
作者：
Langlois-Klassen D;Senthilselvan A;Chui L;Kunimoto D;Saunders LD;Menzies D;Long R
北京病毒株的传播并不比非北京病毒株对公共卫生构成更大的威胁。北京菌株被推测比其他结核分枝杆菌菌株具有选择性优势，因为其具有更高的传播性和毒性。在加拿大接收大量移民的阿尔伯塔省，我们进行了一项基于人群的研究，以确定与非北京毒株相比，北京毒株是否与导致疾病的传播增加有关。在1991-2007年的1,379例肺结核病例中，北京菌株占258例（19%）;总体而言，21%的北京病例和37%的非北京病例与传播集群有关。北京指数病例在2年内的继发病例明显少于非北京病例，但在调整人口统计学特征、传染性和M.结核病谱系在一个结核病得到有效控制的省份，北京菌株的传播并不比非北京菌株对公共卫生构成更多威胁。
Transmission of Beijing strains posed no more of a public health threat than did non-Beijing strains. Beijing strains are speculated to have a selective advantage over other Mycobacterium tuberculosis strains because of increased transmissibility and virulence. In Alberta, a province of Canada that receives a large number of immigrants, we conducted a population-based study to determine whether Beijing strains were associated with increased transmission leading to disease compared with non-Beijing strains. Beijing strains accounted for 258 (19%) of 1,379 pulmonary tuberculosis cases in 1991–2007; overall, 21% of Beijing cases and 37% of non-Beijing cases were associated with transmission clusters. Beijing index cases had significantly fewer secondary cases within 2 years than did non-Beijing cases, but this difference disappeared after adjustment for demographic characteristics, infectiousness, and M. tuberculosis lineage. In a province that has effective tuberculosis control, transmission of Beijing strains posed no more of a public health threat than did non-Beijing strains.
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影响因子：
3.7
作者：
Langlois-Klassen D;Kunimoto D;Saunders LD;Chui L;Boffa J;Menzies D;Long R
通讯作者：
Long R
北京基因型的耐药结核分枝杆菌并未在瑞典传播。
影响因子：
3.7
作者：
Ghebremichael, Solomon;Groenheit, Ramona;Pennhag, Alexandra;Koivula, Tuija;Andersson, Emmi;Bruchfeld, Judith;Hoffner, Sven;Romanus, Victoria;Kallenius, Gunilla
通讯作者：
Kallenius, Gunilla
DOI：
10.1016/j.ddmec.2010.09.004
发表时间：
2010
期刊：
Drug discovery today. Disease mechanisms
影响因子：
--
作者：
Coscolla, Mireilla;Gagneux, Sebastien
通讯作者：
Gagneux, Sebastien
影响因子：
11.8
作者：
Cowley, Donna;Govender, Dhirendra;Nicol, Mark P.
通讯作者：
Nicol, Mark P.
影响因子：
24.3
作者：
Langlois-Klassen, D.;Wooldrage, K. M.;Long, R.
通讯作者：
Long, R.