Nutrient transport in human annulus fibrosus is affected by compressive strain and anisotropy.
Nutrient transport in human annulus fibrosus is affected by compressive strain and anisotropy.
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DOI：
10.1007/s10439-012-0606-4
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发表时间：
2012-12
影响因子：
3.8
通讯作者：
Gu, Wei Yong
中科院分区：
文献类型：
--
作者：
Jackson, Alicia R.;Yuan, Tai-Yi;Huang, Chun-Yuh;Brown, Mark D.;Gu, Wei Yong
无血管间盘(IVD)通过周围血管运输获得营养，营养不良被认为是导致椎间盘退变的主要原因。在这项研究中，我们研究了机械变形和各向异性对人纤维环(AF)中两种重要营养物质--氧和葡萄糖--运输的影响。氧和葡萄糖的扩散率是在三个单轴压缩水平下测量的-0%、10%和20%-以及三个方向-轴向、圆周和径向。还测量了三种压缩水平下的葡萄糖分配系数。结果房颤患者的葡萄糖和氧气扩散系数范围为4.46×10−7~9.77×10−6cm2/S，与前人的研究结果相似，葡萄糖分配系数为0.71~0.82，与前人的结果相似。研究发现，随着变形的增加，传输性能降低，这可能是由于组织压缩过程中的液体渗出和孔尺寸的减小造成的。此外，径向的扩散系数小于轴向和周向的扩散系数，这表明人体房颤中养分的运输是各向异性的。这种行为可能是房颤组织的层状结构和独特的胶原蛋白结构的结果。这些发现对于更好地了解IVD和相关的椎间盘退变的营养供应是很重要的。
The avascular intervertebral disc (IVD) receives nutrition via transport from surrounding vasculature; poor nutrition is believed to be a main cause of disc degeneration. In this study, we investigated the effects of mechanical deformation and anisotropy on the transport of two important nutrients – oxygen and glucose – in human annulus fibrosus (AF). The diffusivities of oxygen and glucose were measured under three levels of uniaxial confined compression – 0%, 10%, and 20% – and in three directions – axial, circumferential, and radial. The glucose partition coefficient was also measured at three compression levels. Results for glucose and oxygen diffusivity in AF ranged from 4.46×10−7 to 9.77×10−6 cm2/s and were comparable to previous studies; the glucose partition coefficient ranged from 0.71 to 0.82 and was also similar to previous results. Transport properties were found to decrease with increasing deformation, likely caused by fluid exudation during tissue compression and reduction in pore size. Furthermore, diffusivity in the radial direction was lower than in the axial or circumferential directions, indicating that nutrient transport in human AF is anisotropic. This behavior is likely a consequence of the layered structure and unique collagen architecture of AF tissue. These findings are important for better understanding nutritional supply in IVD and related disc degeneration.
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影响因子：
2.8
作者：
Fetter, NL;Leddy, HA;Nunley, JA
通讯作者：
Nunley, JA
影响因子：
3
作者：
MARCHAND, F;AHMED, AM
通讯作者：
AHMED, AM
影响因子：
3
作者：
BROWN M D;TSALTAS T T
通讯作者：
TSALTAS T T
DOI：
10.3109/17453677008991550
发表时间：
1970-01-01
期刊：
ACTA ORTHOPAEDICA SCANDINAVICA
影响因子：
--
作者：
NACHEMSON, A;LEWIN, T;FREEMAN, MAR
通讯作者：
FREEMAN, MAR
影响因子：
3
作者：
KRAEMER, J;KOLDITZ, D;GOWIN, R
通讯作者：
GOWIN, R